The dyslexia candidate locus on 2p12 is associated with general cognitive ability and white matter structure
Independent studies have shown that candidate genes for dyslexia and specific language impairment (SLI) impact upon reading/language-specific traits in the general population. To further explore the effect of disorder-associated genes on cognitive functions, we investigated whether they play a role...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Public Library of Science
2012
|
| _version_ | 1797057684196818944 |
|---|---|
| author | Scerri, T Darki, F Newbury, D Whitehouse, A Peyrard-Janvid, M Matsson, H Ang, Q Pennell, C Ring, S Stein, J Morris, A Monaco, A Kere, J Talcott, J Klingberg, T Paracchini, S |
| author_facet | Scerri, T Darki, F Newbury, D Whitehouse, A Peyrard-Janvid, M Matsson, H Ang, Q Pennell, C Ring, S Stein, J Morris, A Monaco, A Kere, J Talcott, J Klingberg, T Paracchini, S |
| author_sort | Scerri, T |
| collection | OXFORD |
| description | Independent studies have shown that candidate genes for dyslexia and specific language impairment (SLI) impact upon reading/language-specific traits in the general population. To further explore the effect of disorder-associated genes on cognitive functions, we investigated whether they play a role in broader cognitive traits. We tested a panel of dyslexia and SLI genetic risk factors for association with two measures of general cognitive abilities, or IQ, (verbal and non-verbal) in the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort (N>5,000). Only the MRPL19/C2ORF3 locus showed statistically significant association (minimum P = 0.00009) which was further supported by independent replications following analysis in four other cohorts. In addition, a fifth independent sample showed association between the MRPL19/C2ORF3 locus and white matter structure in the posterior part of the corpus callosum and cingulum, connecting large parts of the cortex in the parietal, occipital and temporal lobes. These findings suggest that this locus, originally identified as being associated with dyslexia, is likely to harbour genetic variants associated with general cognitive abilities by influencing white matter structure in localised neuronal regions. |
| first_indexed | 2024-03-06T19:39:54Z |
| format | Journal article |
| id | oxford-uuid:204c06fd-0da1-48e2-9293-eab13cb678f3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:39:54Z |
| publishDate | 2012 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:204c06fd-0da1-48e2-9293-eab13cb678f32022-03-26T11:26:51ZThe dyslexia candidate locus on 2p12 is associated with general cognitive ability and white matter structureJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:204c06fd-0da1-48e2-9293-eab13cb678f3EnglishSymplectic Elements at OxfordPublic Library of Science2012Scerri, TDarki, FNewbury, DWhitehouse, APeyrard-Janvid, MMatsson, HAng, QPennell, CRing, SStein, JMorris, AMonaco, AKere, JTalcott, JKlingberg, TParacchini, SIndependent studies have shown that candidate genes for dyslexia and specific language impairment (SLI) impact upon reading/language-specific traits in the general population. To further explore the effect of disorder-associated genes on cognitive functions, we investigated whether they play a role in broader cognitive traits. We tested a panel of dyslexia and SLI genetic risk factors for association with two measures of general cognitive abilities, or IQ, (verbal and non-verbal) in the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort (N>5,000). Only the MRPL19/C2ORF3 locus showed statistically significant association (minimum P = 0.00009) which was further supported by independent replications following analysis in four other cohorts. In addition, a fifth independent sample showed association between the MRPL19/C2ORF3 locus and white matter structure in the posterior part of the corpus callosum and cingulum, connecting large parts of the cortex in the parietal, occipital and temporal lobes. These findings suggest that this locus, originally identified as being associated with dyslexia, is likely to harbour genetic variants associated with general cognitive abilities by influencing white matter structure in localised neuronal regions. |
| spellingShingle | Scerri, T Darki, F Newbury, D Whitehouse, A Peyrard-Janvid, M Matsson, H Ang, Q Pennell, C Ring, S Stein, J Morris, A Monaco, A Kere, J Talcott, J Klingberg, T Paracchini, S The dyslexia candidate locus on 2p12 is associated with general cognitive ability and white matter structure |
| title | The dyslexia candidate locus on 2p12 is associated with general cognitive ability and white matter structure |
| title_full | The dyslexia candidate locus on 2p12 is associated with general cognitive ability and white matter structure |
| title_fullStr | The dyslexia candidate locus on 2p12 is associated with general cognitive ability and white matter structure |
| title_full_unstemmed | The dyslexia candidate locus on 2p12 is associated with general cognitive ability and white matter structure |
| title_short | The dyslexia candidate locus on 2p12 is associated with general cognitive ability and white matter structure |
| title_sort | dyslexia candidate locus on 2p12 is associated with general cognitive ability and white matter structure |
| work_keys_str_mv | AT scerrit thedyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT darkif thedyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT newburyd thedyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT whitehousea thedyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT peyrardjanvidm thedyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT matssonh thedyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT angq thedyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT pennellc thedyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT rings thedyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT steinj thedyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT morrisa thedyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT monacoa thedyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT kerej thedyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT talcottj thedyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT klingbergt thedyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT paracchinis thedyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT scerrit dyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT darkif dyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT newburyd dyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT whitehousea dyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT peyrardjanvidm dyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT matssonh dyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT angq dyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT pennellc dyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT rings dyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT steinj dyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT morrisa dyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT monacoa dyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT kerej dyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT talcottj dyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT klingbergt dyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure AT paracchinis dyslexiacandidatelocuson2p12isassociatedwithgeneralcognitiveabilityandwhitematterstructure |