Molecular classification improves risk assessment in adult BCR-ABL1–negative B-ALL

Molecular classification improves risk assessment in adult BCR-ABL1–negative B-ALL

Genomic classification has improved risk assignment of pediatric, but not adult B-lineage acute lymphoblastic leukemia (B-ALL). The international UKALLXII/ECOG-ACRIN E2993 (#NCT00002514) trial accrued 1229 adolescent/adult patients with BCR-ABL1− B-ALL (aged 14 to 65 years). Although 93% of patients...

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Main Authors: Paietta, E, Roberts, KG, Wang, V, Gu, Z, Buck, GAN, Pei, D, Cheng, C, Levine, RL, Abdel-Wahab, O, Cheng, Z, Wu, G, Qu, C, Shi, L, Pounds, S, Willman, CL, Harvey, R, Racevskis, J, Barinka, J, Zhang, Y, Dewald, GW, Ketterling, RP, Alejos, D, Lazarus, HM, Luger, SM, Foroni, L, Patel, B, Fielding, AK, Melnick, A, Marks, DI, Moorman, AV, Wiernik, PH, Rowe, JM, Tallman, MS, Goldstone, AH, Mullighan, CG, Litzow, MR
Format: Journal article
Language:English
Published: American Society of Hematology 2021

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