Plasma biomarker profile alterations during variable blood storage

A major confounding factor in the discovery of disease-specific molecular signatures is the variability in handling clinical blood samples. Consequently, novel protein markers of diseases have failed the “iron test” of validation and implementation into clinical practice because, in addition to pati...

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Bibliographic Details
Main Authors: Kaisar, M, van Dullemen, L, Thezenas, M, Charles, P, Ploeg, R, Kessler, B
Format: Journal article
Published: American Association for Clinical Chemistry 2016
Description
Summary:A major confounding factor in the discovery of disease-specific molecular signatures is the variability in handling clinical blood samples. Consequently, novel protein markers of diseases have failed the “iron test” of validation and implementation into clinical practice because, in addition to patient variability, a range of preanalytical parameters contributes to erroneous results.