Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans.
The finding that oxygenase-catalyzed protein hydroxylation regulates animal transcription raises questions as to whether the translation machinery and prokaryotic proteins are analogously modified. Escherichia coli ycfD is a growth-regulating 2-oxoglutarate oxygenase catalyzing arginyl hydroxylation...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1826262730902863872 |
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| author | Ge, W Wolf, A Feng, T Ho, C Sekirnik, R Zayer, A Granatino, N Cockman, M Loenarz, C Loik, N Hardy, A Claridge, T Hamed, R Chowdhury, R Gong, L Robinson, C Trudgian, D Jiang, M Mackeen, M McCullagh, J Gordiyenko, Y Thalhammer, A Yamamoto, A Yang, M Liu-Yi, P |
| author_facet | Ge, W Wolf, A Feng, T Ho, C Sekirnik, R Zayer, A Granatino, N Cockman, M Loenarz, C Loik, N Hardy, A Claridge, T Hamed, R Chowdhury, R Gong, L Robinson, C Trudgian, D Jiang, M Mackeen, M McCullagh, J Gordiyenko, Y Thalhammer, A Yamamoto, A Yang, M Liu-Yi, P |
| author_sort | Ge, W |
| collection | OXFORD |
| description | The finding that oxygenase-catalyzed protein hydroxylation regulates animal transcription raises questions as to whether the translation machinery and prokaryotic proteins are analogously modified. Escherichia coli ycfD is a growth-regulating 2-oxoglutarate oxygenase catalyzing arginyl hydroxylation of the ribosomal protein Rpl16. Human ycfD homologs, Myc-induced nuclear antigen (MINA53) and NO66, are also linked to growth and catalyze histidyl hydroxylation of Rpl27a and Rpl8, respectively. This work reveals new therapeutic possibilities via oxygenase inhibition and by targeting modified over unmodified ribosomes. |
| first_indexed | 2024-03-06T19:40:42Z |
| format | Journal article |
| id | oxford-uuid:20947b6a-1e4e-4bb5-951b-4d57edee4d70 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:40:42Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:20947b6a-1e4e-4bb5-951b-4d57edee4d702022-03-26T11:28:19ZOxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:20947b6a-1e4e-4bb5-951b-4d57edee4d70EnglishSymplectic Elements at Oxford2012Ge, WWolf, AFeng, THo, CSekirnik, RZayer, AGranatino, NCockman, MLoenarz, CLoik, NHardy, AClaridge, THamed, RChowdhury, RGong, LRobinson, CTrudgian, DJiang, MMackeen, MMcCullagh, JGordiyenko, YThalhammer, AYamamoto, AYang, MLiu-Yi, PThe finding that oxygenase-catalyzed protein hydroxylation regulates animal transcription raises questions as to whether the translation machinery and prokaryotic proteins are analogously modified. Escherichia coli ycfD is a growth-regulating 2-oxoglutarate oxygenase catalyzing arginyl hydroxylation of the ribosomal protein Rpl16. Human ycfD homologs, Myc-induced nuclear antigen (MINA53) and NO66, are also linked to growth and catalyze histidyl hydroxylation of Rpl27a and Rpl8, respectively. This work reveals new therapeutic possibilities via oxygenase inhibition and by targeting modified over unmodified ribosomes. |
| spellingShingle | Ge, W Wolf, A Feng, T Ho, C Sekirnik, R Zayer, A Granatino, N Cockman, M Loenarz, C Loik, N Hardy, A Claridge, T Hamed, R Chowdhury, R Gong, L Robinson, C Trudgian, D Jiang, M Mackeen, M McCullagh, J Gordiyenko, Y Thalhammer, A Yamamoto, A Yang, M Liu-Yi, P Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. |
| title | Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. |
| title_full | Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. |
| title_fullStr | Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. |
| title_full_unstemmed | Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. |
| title_short | Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. |
| title_sort | oxygenase catalyzed ribosome hydroxylation occurs in prokaryotes and humans |
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