3D growth of cancer cells elicits sensitivity to kinase inhibitors but not lipid metabolism modifiers
Tumor cells exhibit altered lipid metabolism compared with normal cells. Cell signaling kinases are important for regulating lipid synthesis and energy storage. How upstream kinases regulate lipid content, versus direct targeting of lipid-metabolizing enzymes, is currently unexplored. We evaluated i...
Autori principali: | Jones, DT, Valli, A, Haider, S, Zhang, Q, Smethurst, EA, Schug, ZT, Peck, B, Aboagye, EO, Critchlow, SE, Schulze, A, Gottlieb, E, Wakelam, MJO, Harris, AL |
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Natura: | Journal article |
Lingua: | English |
Pubblicazione: |
American Association for Cancer Research
2018
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