3D growth of cancer cells elicits sensitivity to kinase inhibitors but not lipid metabolism modifiers

3D growth of cancer cells elicits sensitivity to kinase inhibitors but not lipid metabolism modifiers

Tumor cells exhibit altered lipid metabolism compared with normal cells. Cell signaling kinases are important for regulating lipid synthesis and energy storage. How upstream kinases regulate lipid content, versus direct targeting of lipid-metabolizing enzymes, is currently unexplored. We evaluated i...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy:	Jones, DT, Valli, A, Haider, S, Zhang, Q, Smethurst, EA, Schug, ZT, Peck, B, Aboagye, EO, Critchlow, SE, Schulze, A, Gottlieb, E, Wakelam, MJO, Harris, AL
Format:	Journal article
Język:	English
Wydane:	American Association for Cancer Research 2018

Podobne zapisy

Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments
od: Peck, B, i wsp.
Wydane: (2016)

Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation.
od: Bensaad, K, i wsp.
Wydane: (2014)

Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
od: Griffiths, Beatrice, i wsp.
Wydane: (2013)

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development
od: Franziska Baenke, i wsp.
Wydane: (2013-11-01)

Infection-derived lipids elicit an immune deficiency circuit in arthropods
od: Dana K. Shaw, i wsp.
Wydane: (2017-02-01)

Lipid activation of protein kinases
od: Alexandra C. Newton
Wydane: (2009-01-01)

Mechanism of activation and autophosphorylation of a histidine kinase
od: Mayukh Kansari, i wsp.
Wydane: (2024-09-01)

Imaging the rapid yet transient accumulation of regulatory lipids, lipid kinases, and protein kinases during membrane fusion, at sites of exocytosis of MMP-9 in MCF-7 cells
od: Dominique C. Stephens, i wsp.
Wydane: (2020-08-01)

Targeting of Protein Kinase CK2 Elicits Antiviral Activity on Bovine Coronavirus Infection
od: Ailyn C. Ramón, i wsp.
Wydane: (2022-03-01)

Immunomodulatory Activity of Tyrosine Kinase Inhibitors to Elicit Cytotoxicity Against Cancer and Viral Infection
od: Núria Climent, i wsp.
Wydane: (2019-10-01)

Extracellular vesicles: lipids as key components of their biogenesis and functions
od: Michel Record, i wsp.
Wydane: (2018-08-01)

Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation
od: Karim Bensaad, i wsp.
Wydane: (2014-10-01)

A Francisella mutant in lipid A carbohydrate modification elicits protective immunity.
od: Duangjit Kanistanon, i wsp.
Wydane: (2008-02-01)

Defense related decadienal elicits membrane lipid remodeling in the diatom Phaeodactylum tricornutum.
od: Tanya Sabharwal, i wsp.
Wydane: (2017-01-01)

Physical exercise elicits UPRmt in the skeletal muscle: The role of c-Jun N-terminal kinase
od: Rodrigo Stellzer Gaspar, i wsp.
Wydane: (2023-12-01)

Aurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma
od: Trang T. T. Nguyen, i wsp.
Wydane: (2021-09-01)

Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation
od: Bensaad, Karim, i wsp.
Wydane: (2016)

Structure of membrane diacylglycerol kinase in lipid bilayers
od: Jianping Li, i wsp.
Wydane: (2021-03-01)

The Phospholipase D2 Knock Out Mouse Has Ectopic Purkinje Cells and Suffers from Early Adult-Onset Anosmia.
od: Matthieu M Vermeren, i wsp.
Wydane: (2016-01-01)

Combination therapy with protein kinase inhibitor H89 and Tetrandrine elicits enhanced synergistic antitumor efficacy
od: Man Yu, i wsp.
Wydane: (2018-06-01)

Lipid and protein structures in the permeability barrier of mammalian epidermis.
od: DT Downing
Wydane: (1992-03-01)

Visual Outcome of Cataract Surgeries Performed in A Rural Eye Care Facility in the Philippines: A One-Year Retrospective Study
od: Chu JPO, i wsp.
Wydane: (2024-08-01)

Iterative selection of lipid nanoparticle vaccine adjuvants for rapid elicitation of tumoricidal CD8⁺ T cells
od: Yuan Luo, i wsp.
Wydane: (2025-06-01)

Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages
od: Mano R. Maurya, i wsp.
Wydane: (2013-09-01)

Metabolic control by S6 kinases depends on dietary lipids.
od: Tamara R Castañeda, i wsp.
Wydane: (2012-01-01)

The unmasking of the lipid binding face of sphingosine kinase 11
od: Robert V. Stahelin
Wydane: (2018-03-01)

Nitrite is produced by elicited but not by circulating neutrophils
od: A. G. Stewart, i wsp.
Wydane: (1993-01-01)

Branched-chain fatty acids in lipids of the newly born lamb
od: D.T. Downing
Wydane: (1964-04-01)

Anaplasma phagocytophilum invasin AipA interacts with CD13 to elicit Src kinase signaling that promotes infection
od: Mary Clark H. Lind, i wsp.
Wydane: (2024-10-01)

Immunomodulatory Activity of the Tyrosine Kinase Inhibitor Dasatinib to Elicit NK Cytotoxicity against Cancer, HIV Infection and Aging
od: Andrea Rodríguez-Agustín, i wsp.
Wydane: (2023-03-01)

Histone deacetylase 4 and 5 translocation elicited by microsecond pulsed electric field exposure is mediated by kinase activity
od: Zahra Safaei, i wsp.
Wydane: (2022-11-01)

Where Do Universal Human Rights Begin?
od: George Critchlow
Wydane: (2006-01-01)

Update of the LIPID MAPS comprehensive classification system for lipids1
od: Eoin Fahy, i wsp.
Wydane: (2009-01-01)

Vaccine-elicited and naturally elicited antibodies differ in their recognition of the HIV-1 fusion peptide
od: Mateo Reveiz, i wsp.
Wydane: (2024-11-01)

Characterization of Salmonella typhimurium YegS, a putative lipid kinase homologous to eukaryotic sphingosine and diacylglycerol kinases.
od: Nichols, C, i wsp.
Wydane: (2007)

Melittin-lipid nanoparticles target to lymph nodes and elicit a systemic anti-tumor immune response
od: Xiang Yu, i wsp.
Wydane: (2020-02-01)

Salicylate-Elicited Activation of AMP-Activated Protein Kinase Directly Triggers Degradation of C-Myc in Colorectal Cancer Cells
od: Ana Laura S. A. Matos, i wsp.
Wydane: (2025-02-01)

Fyn Tyrosine Kinase Elicits Amyloid Precursor Protein Tyr682 Phosphorylation in Neurons from Alzheimer’s Disease Patients
od: Filomena Iannuzzi, i wsp.
Wydane: (2020-07-01)

Self-efficacy, agency and empowerment during adolescence and young adulthood in Ethiopia, India, Peru and Vietnam
od: Espinoza Revollo, P, i wsp.
Wydane: (2019)

Impact of Selected Small-Molecule Kinase Inhibitors on Lipid Membranes
od: Meike Luck, i wsp.
Wydane: (2021-07-01)