3D growth of cancer cells elicits sensitivity to kinase inhibitors but not lipid metabolism modifiers

3D growth of cancer cells elicits sensitivity to kinase inhibitors but not lipid metabolism modifiers

Tumor cells exhibit altered lipid metabolism compared with normal cells. Cell signaling kinases are important for regulating lipid synthesis and energy storage. How upstream kinases regulate lipid content, versus direct targeting of lipid-metabolizing enzymes, is currently unexplored. We evaluated i...

書目詳細資料
Main Authors:	Jones, DT, Valli, A, Haider, S, Zhang, Q, Smethurst, EA, Schug, ZT, Peck, B, Aboagye, EO, Critchlow, SE, Schulze, A, Gottlieb, E, Wakelam, MJO, Harris, AL
格式:	Journal article
語言:	English
出版:	American Association for Cancer Research 2018

相似書籍

Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments
由: Peck, B, et al.
出版: (2016)

Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation.
由: Bensaad, K, et al.
出版: (2014)

Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
由: Griffiths, Beatrice, et al.
出版: (2013)

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development
由: Franziska Baenke, et al.
出版: (2013-11-01)

Lipid activation of protein kinases
由: Alexandra C. Newton
出版: (2009-01-01)

Mechanism of activation and autophosphorylation of a histidine kinase
由: Mayukh Kansari, et al.
出版: (2024-09-01)

Imaging the rapid yet transient accumulation of regulatory lipids, lipid kinases, and protein kinases during membrane fusion, at sites of exocytosis of MMP-9 in MCF-7 cells
由: Dominique C. Stephens, et al.
出版: (2020-08-01)

Targeting of Protein Kinase CK2 Elicits Antiviral Activity on Bovine Coronavirus Infection
由: Ailyn C. Ramón, et al.
出版: (2022-03-01)

Immunomodulatory Activity of Tyrosine Kinase Inhibitors to Elicit Cytotoxicity Against Cancer and Viral Infection
由: Núria Climent, et al.
出版: (2019-10-01)

Extracellular vesicles: lipids as key components of their biogenesis and functions
由: Michel Record, et al.
出版: (2018-08-01)

Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation
由: Karim Bensaad, et al.
出版: (2014-10-01)

A Francisella mutant in lipid A carbohydrate modification elicits protective immunity.
由: Duangjit Kanistanon, et al.
出版: (2008-02-01)

Defense related decadienal elicits membrane lipid remodeling in the diatom Phaeodactylum tricornutum.
由: Tanya Sabharwal, et al.
出版: (2017-01-01)

Physical exercise elicits UPRmt in the skeletal muscle: The role of c-Jun N-terminal kinase
由: Rodrigo Stellzer Gaspar, et al.
出版: (2023-12-01)

Aurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma
由: Trang T. T. Nguyen, et al.
出版: (2021-09-01)

Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation
由: Bensaad, Karim, et al.
出版: (2016)

Structure of membrane diacylglycerol kinase in lipid bilayers
由: Jianping Li, et al.
出版: (2021-03-01)

The Phospholipase D2 Knock Out Mouse Has Ectopic Purkinje Cells and Suffers from Early Adult-Onset Anosmia.
由: Matthieu M Vermeren, et al.
出版: (2016-01-01)

Combination therapy with protein kinase inhibitor H89 and Tetrandrine elicits enhanced synergistic antitumor efficacy
由: Man Yu, et al.
出版: (2018-06-01)

Lipid and protein structures in the permeability barrier of mammalian epidermis.
由: DT Downing
出版: (1992-03-01)

Metabolic control by S6 kinases depends on dietary lipids.
由: Tamara R Castañeda, et al.
出版: (2012-01-01)

The unmasking of the lipid binding face of sphingosine kinase 11
由: Robert V. Stahelin
出版: (2018-03-01)

Iterative selection of lipid nanoparticle vaccine adjuvants for rapid elicitation of tumoricidal CD8⁺ T cells
由: Yuan Luo, et al.
出版: (2025-06-01)

Branched-chain fatty acids in lipids of the newly born lamb
由: D.T. Downing
出版: (1964-04-01)

Anaplasma phagocytophilum invasin AipA interacts with CD13 to elicit Src kinase signaling that promotes infection
由: Mary Clark H. Lind, et al.
出版: (2024-10-01)

Immunomodulatory Activity of the Tyrosine Kinase Inhibitor Dasatinib to Elicit NK Cytotoxicity against Cancer, HIV Infection and Aging
由: Andrea Rodríguez-Agustín, et al.
出版: (2023-03-01)

Histone deacetylase 4 and 5 translocation elicited by microsecond pulsed electric field exposure is mediated by kinase activity
由: Zahra Safaei, et al.
出版: (2022-11-01)

Nitrite is produced by elicited but not by circulating neutrophils
由: A. G. Stewart, et al.
出版: (1993-01-01)

Visual Outcome of Cataract Surgeries Performed in A Rural Eye Care Facility in the Philippines: A One-Year Retrospective Study
由: Chu JPO, et al.
出版: (2024-08-01)

Where Do Universal Human Rights Begin?
由: George Critchlow
出版: (2006-01-01)

Vaccine-elicited and naturally elicited antibodies differ in their recognition of the HIV-1 fusion peptide
由: Mateo Reveiz, et al.
出版: (2024-11-01)

Characterization of Salmonella typhimurium YegS, a putative lipid kinase homologous to eukaryotic sphingosine and diacylglycerol kinases.
由: Nichols, C, et al.
出版: (2007)

Melittin-lipid nanoparticles target to lymph nodes and elicit a systemic anti-tumor immune response
由: Xiang Yu, et al.
出版: (2020-02-01)

Salicylate-Elicited Activation of AMP-Activated Protein Kinase Directly Triggers Degradation of C-Myc in Colorectal Cancer Cells
由: Ana Laura S. A. Matos, et al.
出版: (2025-02-01)

Fyn Tyrosine Kinase Elicits Amyloid Precursor Protein Tyr682 Phosphorylation in Neurons from Alzheimer’s Disease Patients
由: Filomena Iannuzzi, et al.
出版: (2020-07-01)

Impact of Selected Small-Molecule Kinase Inhibitors on Lipid Membranes
由: Meike Luck, et al.
出版: (2021-07-01)

The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold
由: Shi-Hui Dong, et al.
出版: (2015-07-01)

Targeted memory reactivation in human REM sleep elicits detectable reactivation
由: Mahmoud EA Abdellahi, et al.
出版: (2023-06-01)

Self-efficacy, agency and empowerment during adolescence and young adulthood in Ethiopia, India, Peru and Vietnam
由: Espinoza Revollo, P, et al.
出版: (2019)

Multiple TLRs elicit alternative NLRP3 inflammasome activation in primary human monocytes independent of RIPK1 kinase activity
由: Sarah Unterberger, et al.
出版: (2023-10-01)