A randomized control trial of phototherapy and 20% albumin versus phototherapy and saline in Kilifi, Kenya
<p><strong>Objective</strong></p> The study evaluated the efficacy of phototherapy and 20% albumin infusion to reduce total serum bilirubin (TSB) in neonates with severe hyperbilirubinemia. The primary outcome was a reduction of TSB at the end of treatment. The secondary outc...
| Автори: | , , , , , , , , |
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| Формат: | Journal article |
| Мова: | English |
| Опубліковано: |
BioMed Central
2019
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| _version_ | 1826262757169692672 |
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| author | Magai, D Mwaniki, M Abubakar, A Mohammed, S Gordon, A Kalu, R Mwangi, P Koot, H Newton, C |
| author_facet | Magai, D Mwaniki, M Abubakar, A Mohammed, S Gordon, A Kalu, R Mwangi, P Koot, H Newton, C |
| author_sort | Magai, D |
| collection | OXFORD |
| description | <p><strong>Objective</strong></p> The study evaluated the efficacy of phototherapy and 20% albumin infusion to reduce total serum bilirubin (TSB) in neonates with severe hyperbilirubinemia. The primary outcome was a reduction of TSB at the end of treatment. The secondary outcomes were the need for exchange transfusion, inpatient mortality, neurological outcomes at discharge, and development outcomes at 12-months follow-up. <p><strong>Results</strong></p> One hundred and eighteen neonates were randomly assigned to phototherapy and 20% albumin (n = 59) and phototherapy and saline (n = 69). The median age at admission was 5 (interquartile range (IQR) 3–6) days, and the median gestation was 36 (IQR 36–38) weeks. No significant differences were found in the change in TSB (Mann–Whitney U =609, p = 0.98) and rate of change in TSB per hour after treatment (Mann–Whitney U = 540, p = 0.39) between the two groups. There were no significant differences between the two groups in the proportion of participants who required exchange transfusion (χ2 (2) = 0.36, p = 0.546); repeat phototherapy (χ2 (2) = 2.37, p = 0.123); and those who died (χ2 (2) = 0.92, p = 0.337). Trial registration The trial was registered in the International Standardized Randomized Controlled Trial Number (ISRCTN); trial registration number ISRCTN89732754. |
| first_indexed | 2024-03-06T19:41:08Z |
| format | Journal article |
| id | oxford-uuid:20b0898d-259e-45c2-ae11-a0ead8f1861b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:41:08Z |
| publishDate | 2019 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:20b0898d-259e-45c2-ae11-a0ead8f1861b2022-03-26T11:29:00ZA randomized control trial of phototherapy and 20% albumin versus phototherapy and saline in Kilifi, KenyaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:20b0898d-259e-45c2-ae11-a0ead8f1861bEnglishSymplectic Elements at OxfordBioMed Central2019Magai, DMwaniki, MAbubakar, AMohammed, SGordon, AKalu, RMwangi, PKoot, HNewton, C<p><strong>Objective</strong></p> The study evaluated the efficacy of phototherapy and 20% albumin infusion to reduce total serum bilirubin (TSB) in neonates with severe hyperbilirubinemia. The primary outcome was a reduction of TSB at the end of treatment. The secondary outcomes were the need for exchange transfusion, inpatient mortality, neurological outcomes at discharge, and development outcomes at 12-months follow-up. <p><strong>Results</strong></p> One hundred and eighteen neonates were randomly assigned to phototherapy and 20% albumin (n = 59) and phototherapy and saline (n = 69). The median age at admission was 5 (interquartile range (IQR) 3–6) days, and the median gestation was 36 (IQR 36–38) weeks. No significant differences were found in the change in TSB (Mann–Whitney U =609, p = 0.98) and rate of change in TSB per hour after treatment (Mann–Whitney U = 540, p = 0.39) between the two groups. There were no significant differences between the two groups in the proportion of participants who required exchange transfusion (χ2 (2) = 0.36, p = 0.546); repeat phototherapy (χ2 (2) = 2.37, p = 0.123); and those who died (χ2 (2) = 0.92, p = 0.337). Trial registration The trial was registered in the International Standardized Randomized Controlled Trial Number (ISRCTN); trial registration number ISRCTN89732754. |
| spellingShingle | Magai, D Mwaniki, M Abubakar, A Mohammed, S Gordon, A Kalu, R Mwangi, P Koot, H Newton, C A randomized control trial of phototherapy and 20% albumin versus phototherapy and saline in Kilifi, Kenya |
| title | A randomized control trial of phototherapy and 20% albumin versus phototherapy and saline in Kilifi, Kenya |
| title_full | A randomized control trial of phototherapy and 20% albumin versus phototherapy and saline in Kilifi, Kenya |
| title_fullStr | A randomized control trial of phototherapy and 20% albumin versus phototherapy and saline in Kilifi, Kenya |
| title_full_unstemmed | A randomized control trial of phototherapy and 20% albumin versus phototherapy and saline in Kilifi, Kenya |
| title_short | A randomized control trial of phototherapy and 20% albumin versus phototherapy and saline in Kilifi, Kenya |
| title_sort | randomized control trial of phototherapy and 20 albumin versus phototherapy and saline in kilifi kenya |
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