X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate.

X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate.

Studies on the catalytic mechanism and inhibition of serine proteases are widely used as paradigms for teaching enzyme catalysis. Ground-breaking work on the structures of chymotrypsin and subtilisin led to the idea of a conserved catalytic triad formed by the active site Ser, His and Asp residues....

Bibliográfalaš dieđut
Váldodahkkit:	Wilmouth, R, Edman, K, Neutze, R, Wright, P, Clifton, I, Schneider, T, Schofield, C, Hajdu, J
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	2001

Geahča maid

Structural analyses on intermediates in serine protease catalysis.
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Molecular dynamics simulations of the acyl-enzyme and the tetrahedral intermediate in the deacylation step of serine proteases.
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Improved Skin Permeability after Topical Treatment with Serine Protease: Probing the Penetration of Rapamycin by Scanning Transmission X‑ray Microscopy
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X-ray studies on the mechanism of IPNS using substrate analogs
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Sulfonyl fluoride analogues as activity-based probes for serine proteases.
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Fibrinolytic Serine Proteases, Therapeutic Serpins and Inflammation: Fire Dancers and Firestorms
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Natural serine proteases and their applications in combating amyloid formation
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Protein targets of inflammatory serine proteases and cardiovascular disease
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