X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate.

X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate.

Studies on the catalytic mechanism and inhibition of serine proteases are widely used as paradigms for teaching enzyme catalysis. Ground-breaking work on the structures of chymotrypsin and subtilisin led to the idea of a conserved catalytic triad formed by the active site Ser, His and Asp residues....

書目詳細資料
Main Authors:	Wilmouth, R, Edman, K, Neutze, R, Wright, P, Clifton, I, Schneider, T, Schofield, C, Hajdu, J
格式:	Journal article
語言:	English
出版:	2001

相似書籍

Structural analyses on intermediates in serine protease catalysis.
由: Liu, B, et al.
出版: (2006)

X-ray structure of a serine protease acyl-enzyme complex at 0.95-A resolution.
由: Katona, G, et al.
出版: (2002)

Molecular dynamics simulations of the acyl-enzyme and the tetrahedral intermediate in the deacylation step of serine proteases.
由: Topf, M, et al.
出版: (2002)

Mechanistic insights into the inhibition of serine proteases by monocyclic lactams.
由: Wilmouth, R, et al.
出版: (1999)

beta-Sultams - A novel class of serine protease inhibitors
由: Beardsell, M, et al.
出版: (2001)

5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition.
由: Migaud, M, et al.
出版: (2002)

5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition.
由: Migaud, M, et al.
出版: (2002)

Proton Bridging in Catalysis by and Inhibition of Serine Proteases of the Blood Cascade System
由: Ildiko M Kovach
出版: (2021-04-01)

Reaction of clavams with elastase reveals a general method for inhibiting 'serine' enzymes
由: Wilmouth, R, et al.
出版: (2000)

Kinetic and crystallographic analysis of complexes formed between elastase and peptides from beta-casein.
由: Wright, P, et al.
出版: (2001)

'pH-jump' crystallographic analyses of gamma-lactam-porcine pancreatic elastase complexes.
由: Wright, P, et al.
出版: (2000)

New structural insights into the inhibition of serine proteases by cyclic peptides from bacteria.
由: McDonough, M, et al.
出版: (2003)

Genome-wide survey of prokaryotic serine proteases: Analysis of distribution and domain architectures of five serine protease families in prokaryotes
由: Tripathi Lokesh P, et al.
出版: (2008-11-01)

Purification, crystallization and preliminary X-ray diffraction of anthocyanidin synthase from Arabidopsis thaliana.
由: Turnbull, J, et al.
出版: (2001)

Commentary: Fungal lifestyle reflected in serine protease repertoire
由: Ronivaldo R. da Silva
出版: (2018-03-01)

Cross genome comparisons of serine proteases in Arabidopsis and rice
由: Sowdhamini R, et al.
出版: (2006-08-01)

An Epoxide Intermediate in Glycosidase Catalysis
由: Lukasz F. Sobala, et al.
出版: (2020-04-01)

Cyclobutanone mimics of intermediates in metallo-β-lactamase catalysis.
由: Abboud, M, et al.
出版: (2017)

Anatomy of a simple acyl intermediate in enzyme catalysis: combined biophysical and modeling studies on ornithine acetyl transferase.
由: Iqbal, A, et al.
出版: (2009)

Functions and evolution of FAM111 serine proteases
由: Allison L. Welter, et al.
出版: (2022-12-01)

Editorial: Serine protease inhibitors and their therapeutic applications
由: Letizia Crocetti, et al.
出版: (2022-08-01)

Fungal lifestyle reflected in serine protease repertoire
由: Anna Muszewska, et al.
出版: (2017-08-01)

Role of Serine Proteases at the Tumor-Stroma Interface
由: Ravichandra Tagirasa, et al.
出版: (2022-02-01)

Virtual Screening of Transmembrane Serine Protease Inhibitors
由: Antti Poso, et al.
出版: (2017-04-01)

Theoretical Evidence for the Nonoccurrence of Tetrahedral Intermediates in the Deacylation Pathway of the Oxacillinase-24/Avibactam Complex
由: Ignacio Lizana, et al.
出版: (2019-12-01)

Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation
由: Timo Burster, et al.
出版: (2021-11-01)

Preparation and target protease identification of a cyanobacterial serine protease inhibitor, arthropin
由: XU Jiawei, et al.
出版: (2023-04-01)

Improved Skin Permeability after Topical Treatment with Serine Protease: Probing the Penetration of Rapamycin by Scanning Transmission X‑ray Microscopy
由: Gregor Germer, et al.
出版: (2021-04-01)

X-ray studies on the mechanism of IPNS using substrate analogs
由: Long, A, et al.
出版: (1997)

Sulfonyl fluoride analogues as activity-based probes for serine proteases.
由: Shannon, D, et al.
出版: (2012)

Fibrinolytic Serine Proteases, Therapeutic Serpins and Inflammation: Fire Dancers and Firestorms
由: Jordan R. Yaron, et al.
出版: (2021-03-01)

Natural serine proteases and their applications in combating amyloid formation
由: Sanjay Metkar, et al.
出版: (2024-11-01)

The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung
由: Matthew S. Twigg, et al.
出版: (2015-01-01)

Expression and Characterization of Coprothermobacter proteolyticus Alkaline Serine Protease
由: Tanveer Majeed, et al.
出版: (2013-01-01)

In Drosophila Hemolymph, Serine Proteases Are the Major Gelatinases and Caseinases
由: Jean-Luc Gatti, et al.
出版: (2024-03-01)

Serine Protease Autotransporters of Enterobacteriaceae (SPATEs): Biogenesis and Function
由: Nathalie Dautin
出版: (2010-05-01)

Short hydrogen bonds in the catalytic mechanism of serine proteases
由: VLADIMIR LESKOVAC, et al.
出版: (2008-04-01)

Modeling and structural analysis of PA clan serine proteases
由: Laskar Aparna, et al.
出版: (2012-05-01)

Protein targets of inflammatory serine proteases and cardiovascular disease
由: Sharony Ram, et al.
出版: (2010-08-01)

Peptidyl Activity-Based Probes for Imaging Serine Proteases
由: Paulina Kasperkiewicz
出版: (2021-04-01)