Single DNA rotaxanes of a transmembrane pore protein.
Threading a molecular needle: An α-hemolysin transmembrane pore can be threaded in a desired orientation by DNA-poly(ethylene glycol) (DNA-PEG) hybrid strands to yield functional rotaxanes (see figure). The single-molecule rotaxanes are stable and have a reversible two-state switching capacity that...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2004
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| Summary: | Threading a molecular needle: An α-hemolysin transmembrane pore can be threaded in a desired orientation by DNA-poly(ethylene glycol) (DNA-PEG) hybrid strands to yield functional rotaxanes (see figure). The single-molecule rotaxanes are stable and have a reversible two-state switching capacity that depends on the applied potential, orientation, and method of threading and capture used. |
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