An ACAT inhibitor suppresses SARS-CoV-2 replication and boosts antiviral T cell activity

An ACAT inhibitor suppresses SARS-CoV-2 replication and boosts antiviral T cell activity

The severity of disease following infection with SARS-CoV-2 is determined by viral replication kinetics and host immunity, with early T cell responses and/or suppression of viraemia driving a favourable outcome. Recent studies uncovered a role for cholesterol metabolism in the SARS-CoV-2 life cycle...

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Détails bibliographiques
Auteurs principaux:	Wing, PAC, Schmidt, NM, Peters, R, Erdmann, M, Brown, R, Wang, H, Swadling, L, Newman, J, Thakur, N, Shionoya, K, Morgan, SB, Hinks, TSC, Watashi, K, Bailey, D, Hansen, SB, Davidson, AD, Maini, MK, McKeating, JA
Autres auteurs:	COVIDsortium Investigators
Format:	Journal article
Langue:	English
Publié:	Public Library of Science 2023

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