Immune reconstitution inflammatory syndrome and the influence of T regulatory cells: a cohort study in The Gambia.
The factors associated with the development of immune reconstitution inflammatory syndrome in HIV patients commencing antiretroviral therapy have not been fully elucidated. Using a longitudinal study design, this study addressed whether alteration in the levels of T regulatory cells contributed to t...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Public Library of Science
2012
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| _version_ | 1797057813802909696 |
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| author | Zaidi, I Peterson, K Jeffries, D Whittle, H de Silva, T Rowland-Jones, S Jaye, A de Jong, B |
| author_facet | Zaidi, I Peterson, K Jeffries, D Whittle, H de Silva, T Rowland-Jones, S Jaye, A de Jong, B |
| author_sort | Zaidi, I |
| collection | OXFORD |
| description | The factors associated with the development of immune reconstitution inflammatory syndrome in HIV patients commencing antiretroviral therapy have not been fully elucidated. Using a longitudinal study design, this study addressed whether alteration in the levels of T regulatory cells contributed to the development of IRIS in a West African cohort of HIV-1 and HIV-2 patients. Seventy-one HIV infected patients were prospectively recruited to the study and followed up for six months. The patients were categorized as IRIS or non-IRIS cases following published clinical guidelines. The levels of T regulatory cells were measured using flow cytometry at baseline and all follow-up visits. Baseline cytokine levels of IL-2, IL-6, IFN-(Gamma), TNF-(Alpha), MIP-1(Beta), IL-1, IL-12, IL-13, and IL-10 were measured in all patients. |
| first_indexed | 2024-03-06T19:41:45Z |
| format | Journal article |
| id | oxford-uuid:20ec0e2b-e074-4df2-af96-a1fb9baf72a8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:41:45Z |
| publishDate | 2012 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:20ec0e2b-e074-4df2-af96-a1fb9baf72a82022-03-26T11:30:14ZImmune reconstitution inflammatory syndrome and the influence of T regulatory cells: a cohort study in The Gambia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:20ec0e2b-e074-4df2-af96-a1fb9baf72a8EnglishSymplectic Elements at OxfordPublic Library of Science2012Zaidi, IPeterson, KJeffries, DWhittle, Hde Silva, TRowland-Jones, SJaye, Ade Jong, BThe factors associated with the development of immune reconstitution inflammatory syndrome in HIV patients commencing antiretroviral therapy have not been fully elucidated. Using a longitudinal study design, this study addressed whether alteration in the levels of T regulatory cells contributed to the development of IRIS in a West African cohort of HIV-1 and HIV-2 patients. Seventy-one HIV infected patients were prospectively recruited to the study and followed up for six months. The patients were categorized as IRIS or non-IRIS cases following published clinical guidelines. The levels of T regulatory cells were measured using flow cytometry at baseline and all follow-up visits. Baseline cytokine levels of IL-2, IL-6, IFN-(Gamma), TNF-(Alpha), MIP-1(Beta), IL-1, IL-12, IL-13, and IL-10 were measured in all patients. |
| spellingShingle | Zaidi, I Peterson, K Jeffries, D Whittle, H de Silva, T Rowland-Jones, S Jaye, A de Jong, B Immune reconstitution inflammatory syndrome and the influence of T regulatory cells: a cohort study in The Gambia. |
| title | Immune reconstitution inflammatory syndrome and the influence of T regulatory cells: a cohort study in The Gambia. |
| title_full | Immune reconstitution inflammatory syndrome and the influence of T regulatory cells: a cohort study in The Gambia. |
| title_fullStr | Immune reconstitution inflammatory syndrome and the influence of T regulatory cells: a cohort study in The Gambia. |
| title_full_unstemmed | Immune reconstitution inflammatory syndrome and the influence of T regulatory cells: a cohort study in The Gambia. |
| title_short | Immune reconstitution inflammatory syndrome and the influence of T regulatory cells: a cohort study in The Gambia. |
| title_sort | immune reconstitution inflammatory syndrome and the influence of t regulatory cells a cohort study in the gambia |
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