Effects of different antimalarial drugs on gametocyte carriage in P. vivax malaria.
The gametocytocidal and asexual stage activities of eight antimalarial and eight antibiotic-containing regimens were evaluated in 349 adult patients with P. vivax malaria. Gametocytemia was found in 63% of patients (22% before and 41% after treatment). The median (range) gametocyte clearance time wa...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1797057820099608576 |
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| author | Pukrittayakamee, S Imwong, M Singhasivanon, P Stepniewska, K Day, N White, N |
| author_facet | Pukrittayakamee, S Imwong, M Singhasivanon, P Stepniewska, K Day, N White, N |
| author_sort | Pukrittayakamee, S |
| collection | OXFORD |
| description | The gametocytocidal and asexual stage activities of eight antimalarial and eight antibiotic-containing regimens were evaluated in 349 adult patients with P. vivax malaria. Gametocytemia was found in 63% of patients (22% before and 41% after treatment). The median (range) gametocyte clearance time was 24 hours (range, 2-504 hours) and correlated with asexual parasite clearance time (r = 0.52, P < 0.001). Gametocytemia in vivax malaria was more common in patients with admission parasitemia > 10,000/microL and after treatment with drugs which have weak antimalarial activity, and was also associated with an increased rate of vivax reappearance (29.4% versus 14.1%, P = 0.002). Sexual stage activities corresponded with asexual stage activity for all tested regimens. Treatment with potent antimalarial drugs reduces the transmission potential of P. vivax. |
| first_indexed | 2024-03-06T19:41:51Z |
| format | Journal article |
| id | oxford-uuid:20f56a4c-9840-49be-bb3a-e33932222bad |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:41:51Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:20f56a4c-9840-49be-bb3a-e33932222bad2022-03-26T11:30:24ZEffects of different antimalarial drugs on gametocyte carriage in P. vivax malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:20f56a4c-9840-49be-bb3a-e33932222badEnglishSymplectic Elements at Oxford2008Pukrittayakamee, SImwong, MSinghasivanon, PStepniewska, KDay, NWhite, NThe gametocytocidal and asexual stage activities of eight antimalarial and eight antibiotic-containing regimens were evaluated in 349 adult patients with P. vivax malaria. Gametocytemia was found in 63% of patients (22% before and 41% after treatment). The median (range) gametocyte clearance time was 24 hours (range, 2-504 hours) and correlated with asexual parasite clearance time (r = 0.52, P < 0.001). Gametocytemia in vivax malaria was more common in patients with admission parasitemia > 10,000/microL and after treatment with drugs which have weak antimalarial activity, and was also associated with an increased rate of vivax reappearance (29.4% versus 14.1%, P = 0.002). Sexual stage activities corresponded with asexual stage activity for all tested regimens. Treatment with potent antimalarial drugs reduces the transmission potential of P. vivax. |
| spellingShingle | Pukrittayakamee, S Imwong, M Singhasivanon, P Stepniewska, K Day, N White, N Effects of different antimalarial drugs on gametocyte carriage in P. vivax malaria. |
| title | Effects of different antimalarial drugs on gametocyte carriage in P. vivax malaria. |
| title_full | Effects of different antimalarial drugs on gametocyte carriage in P. vivax malaria. |
| title_fullStr | Effects of different antimalarial drugs on gametocyte carriage in P. vivax malaria. |
| title_full_unstemmed | Effects of different antimalarial drugs on gametocyte carriage in P. vivax malaria. |
| title_short | Effects of different antimalarial drugs on gametocyte carriage in P. vivax malaria. |
| title_sort | effects of different antimalarial drugs on gametocyte carriage in p vivax malaria |
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