Species-specific transcriptional regulation of genes involved in nitric oxide production and arginine metabolism in macrophages

Species-specific transcriptional regulation of genes involved in nitric oxide production and arginine metabolism in macrophages

Activated mouse macrophages metabolize arginine via NO synthase (NOS2) to produce NO as an antimicrobial effector. Published gene expression datasets provide little support for the activation of this pathway in human macrophages. Generation of NO requires the coordinated regulation of multiple genes...

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Bibliographic Details
Main Authors:	Young, R, Bush, S, Lefevre, L, McCulloch, M, Lisowski, Z, Muriuki, C, Waddell, L, Sauter, K, Pridans, C, Clark, E, Hume, D
Format:	Journal article
Published:	American Association of Immunologists 2018

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