Reduced beta cell function in offspring of mothers with young-onset type 2 diabetes.

Reduced beta cell function in offspring of mothers with young-onset type 2 diabetes.

Zobrazit další vydání (1)

AIMS/HYPOTHESIS: Animal models indicate that even exposure to mild maternal hyperglycaemia in utero is detrimental to the beta cell function of the offspring, but evidence of this in humans is limited. In Europids who are diagnosed with type 2 diabetes before the age of 50 years, the risk of diabete...

Podrobná bibliografie
Hlavní autoři:	Singh, R, Pearson, E, Avery, P, McCarthy, M, Levy, J, Hitman, G, Sampson, M, Walker, M, Hattersley, A
Médium:	Journal article
Jazyk:	English
Vydáno:	2006

Podobné jednotky

Reduced beta cell function in offspring of mothers with young onset type 2 diabetes
Autor: Singh, R, a další
Vydáno: (2005)

Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes.
Autor: Mills, G, a další
Vydáno: (2004)

Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11.
Autor: Frayling, T, a další
Vydáno: (2003)

Parent-offspring trios: a resource to facilitate the identification of type 2 diabetes genes.
Autor: Frayling, T, a další
Vydáno: (1999)

Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24.
Autor: Wiltshire, S, a další
Vydáno: (2004)

Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset.
Autor: Zeggini, E, a další
Vydáno: (2004)

Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles.
Autor: Huxtable, S, a další
Vydáno: (2000)

Type 2 diabetes transcription factor 7-like 2 (TCF7L2) risk alleles reduce beta-cell function and increase birth weight
Autor: Freathy, R, a další
Vydáno: (2007)

MATURITY-ONSET DIABETES OF THE YOUNG IS A BETA-CELL DISORDER WITH NORMAL PROINSULIN LEVELS
Autor: Hattersley, A, a další
Vydáno: (1993)

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
Autor: Gloyn, A, a další
Vydáno: (2003)

Large-scale association studies of variants in genes encoding the pancreatic beta-cell K-ATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes
Autor: Gloyn, A, a další
Vydáno: (2003)

Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples.
Autor: Zeggini, E, a další
Vydáno: (2005)

Mitochondrial DNA haplogroups and type 2 diabetes: a study of 897 cases and 1010 controls.
Autor: Chinnery, P, a další
Vydáno: (2007)

GAD antibodies in probands and their relatives in a cohort clinically selected for Type 2 diabetes.
Autor: Castleden, H, a další
Vydáno: (2006)

Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes.
Autor: Winckler, W, a další
Vydáno: (2007)

Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects.
Autor: Mitchell, S, a další
Vydáno: (2003)

No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians.
Autor: Weedon, M, a další
Vydáno: (2006)

Assessment of the role of genetic variation in the transient neonatal diabetes (TNDM) region on chromosome 6q24 in type 2 diabetes: a comparative genomic and haplotype approach
Autor: Gloyn, A, a další
Vydáno: (2005)

Role of the D76N polymorphism of insulin promoter factor-1 in predisposing to Type 2 diabetes.
Autor: Owen, K, a další
Vydáno: (2004)

Large-scale association studies of candidate genes and their interactions in Type 2 diabetes
Autor: Zeggini, E, a další
Vydáno: (2004)

Unique blood pressure characteristics in mother and offspring after early onset preeclampsia.
Autor: Lazdam, M, a další
Vydáno: (2012)

Unique blood pressure characteristics in mother and offspring after early onset preeclampsia
Autor: Lazdam, M, a další
Vydáno: (2012)

Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population.
Autor: Freathy, R, a další
Vydáno: (2006)

Common variation in the LMNA gene increases susceptibility to type 2 diabetes
Autor: Owen, K, a další
Vydáno: (2006)

A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population.
Autor: Weedon, M, a další
Vydáno: (2005)

Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate.
Autor: Groves, C, a další
Vydáno: (2006)

Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes.
Autor: Wiltshire, S, a další
Vydáno: (2002)

Susceptibility for latent autoimmune diabetes in adults (LADA) is determined by variation at the 1DDM2 (insulin-gene) locus in white Caucasian patients from UK repositories
Autor: Desai, M, a další
Vydáno: (2005)

The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians
Autor: Freathy, R, a další
Vydáno: (2006)

No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians.
Autor: Frayling, T, a další
Vydáno: (2000)

Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population.
Autor: Patel, S, a další
Vydáno: (2006)

Metabolic flexibility is impaired in response to acute exercise in the young offspring of mothers with type 2 diabetes
Autor: Timothy D. Allerton, a další
Vydáno: (2019-09-01)

Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.
Autor: Groves, C, a další
Vydáno: (2003)

The variable number of tandem repeats upstream of the insulin gene is a susceptibility locus for latent autoimmune diabetes in adults.
Autor: Desai, M, a další
Vydáno: (2006)

Type 2 diabetes and the human homolog of the rat insulin resistance gene, CD36: No linkage or association in Europeans
Autor: McCarthy, M, a další
Vydáno: (1999)

Metabolic profiling in Maturity-onset diabetes of the young (MODY) and young onset type 2 diabetes fails to detect robust urinary biomarkers.
Autor: Gloyn, A, a další
Vydáno: (2012)

Cardiovascular impact of preeclampsia on mother and offspring
Autor: Lazdam, M
Vydáno: (2013)

Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes.
Autor: Zeggini, E, a další
Vydáno: (2005)

Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes.
Autor: Chinnery, P, a další
Vydáno: (2005)

Extending criteria for genetic testing increases diagnosis of maturity-onset diabetes of the young
Autor: Thanabalasingham, G, a další
Vydáno: (2010)