Antiparasitic chaiyaphumines from entomopathogenic Xenorhabdus sp. PB61.4.
A new class of four depsipentapeptides called chaiyaphumines A-D (1-4) was isolated from Xenorhabdus sp. PB61.4. Their structures were elucidated by detailed 1D and 2D NMR experiments and by a Marfey's analysis following flash hydrolysis of the peptide. Verification of the structure was achieve...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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American Chemical Society
2014
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| _version_ | 1797057863771750400 |
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| author | Grundmann, F Kaiser, M Schiell, M Batzer, A Kurz, M Thanwisai, A Chantratita, N Bode, H |
| author_facet | Grundmann, F Kaiser, M Schiell, M Batzer, A Kurz, M Thanwisai, A Chantratita, N Bode, H |
| author_sort | Grundmann, F |
| collection | OXFORD |
| description | A new class of four depsipentapeptides called chaiyaphumines A-D (1-4) was isolated from Xenorhabdus sp. PB61.4. Their structures were elucidated by detailed 1D and 2D NMR experiments and by a Marfey's analysis following flash hydrolysis of the peptide. Verification of the structure was achieved by three-dimensional modeling using NOE-derived distance constraints, molecular dynamics, and energy minimization. Chaiyaphumine A (1) showed good activity against Plasmodium falciparum (IC50 of 0.61 μM), the causative agent of malaria, and was active against other protozoal tropical disease causing agents. |
| first_indexed | 2024-03-06T19:42:27Z |
| format | Journal article |
| id | oxford-uuid:2123db64-42b5-4ab3-a820-47a76b20b27d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:42:27Z |
| publishDate | 2014 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | oxford-uuid:2123db64-42b5-4ab3-a820-47a76b20b27d2022-03-26T11:31:36ZAntiparasitic chaiyaphumines from entomopathogenic Xenorhabdus sp. PB61.4.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2123db64-42b5-4ab3-a820-47a76b20b27dEnglishSymplectic Elements at OxfordAmerican Chemical Society2014Grundmann, FKaiser, MSchiell, MBatzer, AKurz, MThanwisai, AChantratita, NBode, HA new class of four depsipentapeptides called chaiyaphumines A-D (1-4) was isolated from Xenorhabdus sp. PB61.4. Their structures were elucidated by detailed 1D and 2D NMR experiments and by a Marfey's analysis following flash hydrolysis of the peptide. Verification of the structure was achieved by three-dimensional modeling using NOE-derived distance constraints, molecular dynamics, and energy minimization. Chaiyaphumine A (1) showed good activity against Plasmodium falciparum (IC50 of 0.61 μM), the causative agent of malaria, and was active against other protozoal tropical disease causing agents. |
| spellingShingle | Grundmann, F Kaiser, M Schiell, M Batzer, A Kurz, M Thanwisai, A Chantratita, N Bode, H Antiparasitic chaiyaphumines from entomopathogenic Xenorhabdus sp. PB61.4. |
| title | Antiparasitic chaiyaphumines from entomopathogenic Xenorhabdus sp. PB61.4. |
| title_full | Antiparasitic chaiyaphumines from entomopathogenic Xenorhabdus sp. PB61.4. |
| title_fullStr | Antiparasitic chaiyaphumines from entomopathogenic Xenorhabdus sp. PB61.4. |
| title_full_unstemmed | Antiparasitic chaiyaphumines from entomopathogenic Xenorhabdus sp. PB61.4. |
| title_short | Antiparasitic chaiyaphumines from entomopathogenic Xenorhabdus sp. PB61.4. |
| title_sort | antiparasitic chaiyaphumines from entomopathogenic xenorhabdus sp pb61 4 |
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