Vitamin D-gene interactions in multiple sclerosis
Vitamin D has been studied for over a century and its functions related to calcium homeostasis are well established. Over the last 30 years or so it has become increasingly clear that it has a wider role in physiology and, importantly, also in disease. Vitamin D deficiency has been linked to multipl...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1797057867895799808 |
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| author | Berlanga-Taylor, A Disanto, G Ebers, G Ramagopalan, S |
| author_facet | Berlanga-Taylor, A Disanto, G Ebers, G Ramagopalan, S |
| author_sort | Berlanga-Taylor, A |
| collection | OXFORD |
| description | Vitamin D has been studied for over a century and its functions related to calcium homeostasis are well established. Over the last 30 years or so it has become increasingly clear that it has a wider role in physiology and, importantly, also in disease. Vitamin D deficiency has been linked to multiple sclerosis (MS); however the molecular mechanisms of this association were poorly understood. Recent technological advances have provided major insights as to how vitamin D may exert its role, particularly through the actions of the vitamin D receptor (VDR). In this review we aim to highlight the importance of the interaction between vitamin D and MS associated genes which provide a biological basis for the association between vitamin D and MS risk. © 2011 Elsevier B.V. All rights reserved. |
| first_indexed | 2024-03-06T19:42:30Z |
| format | Journal article |
| id | oxford-uuid:2128c50c-d6a3-46ff-85c1-d1d490912eb6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:42:30Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:2128c50c-d6a3-46ff-85c1-d1d490912eb62022-03-26T11:31:43ZVitamin D-gene interactions in multiple sclerosisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2128c50c-d6a3-46ff-85c1-d1d490912eb6EnglishSymplectic Elements at Oxford2011Berlanga-Taylor, ADisanto, GEbers, GRamagopalan, SVitamin D has been studied for over a century and its functions related to calcium homeostasis are well established. Over the last 30 years or so it has become increasingly clear that it has a wider role in physiology and, importantly, also in disease. Vitamin D deficiency has been linked to multiple sclerosis (MS); however the molecular mechanisms of this association were poorly understood. Recent technological advances have provided major insights as to how vitamin D may exert its role, particularly through the actions of the vitamin D receptor (VDR). In this review we aim to highlight the importance of the interaction between vitamin D and MS associated genes which provide a biological basis for the association between vitamin D and MS risk. © 2011 Elsevier B.V. All rights reserved. |
| spellingShingle | Berlanga-Taylor, A Disanto, G Ebers, G Ramagopalan, S Vitamin D-gene interactions in multiple sclerosis |
| title | Vitamin D-gene interactions in multiple sclerosis |
| title_full | Vitamin D-gene interactions in multiple sclerosis |
| title_fullStr | Vitamin D-gene interactions in multiple sclerosis |
| title_full_unstemmed | Vitamin D-gene interactions in multiple sclerosis |
| title_short | Vitamin D-gene interactions in multiple sclerosis |
| title_sort | vitamin d gene interactions in multiple sclerosis |
| work_keys_str_mv | AT berlangataylora vitamindgeneinteractionsinmultiplesclerosis AT disantog vitamindgeneinteractionsinmultiplesclerosis AT ebersg vitamindgeneinteractionsinmultiplesclerosis AT ramagopalans vitamindgeneinteractionsinmultiplesclerosis |