Effects of LTD4 and its specific antagonist L-660,711 in isolated rat hearts with chronic myocardial infarction
We investigated the effects of leukotriene (LT) D4 and its novel potent and selective antagonist L-660,711 on isolated rat hearts with chronic myocardial infarction. The left coronary artery was ligated permanently or for 30 or 60 min and followed by reperfusion. Hearts were isolated and perfused in...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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1994
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| _version_ | 1797057870077886464 |
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| author | Han, H Tian, R Neubauer, S Gaudron, P Hu, K Ertl, G |
| author_facet | Han, H Tian, R Neubauer, S Gaudron, P Hu, K Ertl, G |
| author_sort | Han, H |
| collection | OXFORD |
| description | We investigated the effects of leukotriene (LT) D4 and its novel potent and selective antagonist L-660,711 on isolated rat hearts with chronic myocardial infarction. The left coronary artery was ligated permanently or for 30 or 60 min and followed by reperfusion. Hearts were isolated and perfused in the Langendorff mode 4 days, 4 wk, or 8 wk after the operation. Dose-response curves for LTD4 (12-240 ng/min) on coronary flow were shifted to the left in rats with permanent coronary occlusion for 8 wk or with coronary occlusion for 30 or 60 min and reperfusion for 4 wk. In contrast, dose-response curves were unchanged in rats 4 days after myocardial infarction. L-660,711 shifted dose-response curves for LTD4 on coronary flow to the right in all groups. The negative inotropic and chronotropic effects of LTD4 could be markedly attenuated by L-660,711 in all groups. Our findings suggest that the effect of LTD4 is enhanced in rat hearts with chronic myocardial infarction. L-660,711 effectively antagonized the vasoconstrictor effect of exogenous LTD4. |
| first_indexed | 2024-03-06T19:42:32Z |
| format | Journal article |
| id | oxford-uuid:212acc88-8b92-4236-95fc-4547fbefdb4d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:42:32Z |
| publishDate | 1994 |
| record_format | dspace |
| spelling | oxford-uuid:212acc88-8b92-4236-95fc-4547fbefdb4d2022-03-26T11:31:49ZEffects of LTD4 and its specific antagonist L-660,711 in isolated rat hearts with chronic myocardial infarctionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:212acc88-8b92-4236-95fc-4547fbefdb4dEnglishSymplectic Elements at Oxford1994Han, HTian, RNeubauer, SGaudron, PHu, KErtl, GWe investigated the effects of leukotriene (LT) D4 and its novel potent and selective antagonist L-660,711 on isolated rat hearts with chronic myocardial infarction. The left coronary artery was ligated permanently or for 30 or 60 min and followed by reperfusion. Hearts were isolated and perfused in the Langendorff mode 4 days, 4 wk, or 8 wk after the operation. Dose-response curves for LTD4 (12-240 ng/min) on coronary flow were shifted to the left in rats with permanent coronary occlusion for 8 wk or with coronary occlusion for 30 or 60 min and reperfusion for 4 wk. In contrast, dose-response curves were unchanged in rats 4 days after myocardial infarction. L-660,711 shifted dose-response curves for LTD4 on coronary flow to the right in all groups. The negative inotropic and chronotropic effects of LTD4 could be markedly attenuated by L-660,711 in all groups. Our findings suggest that the effect of LTD4 is enhanced in rat hearts with chronic myocardial infarction. L-660,711 effectively antagonized the vasoconstrictor effect of exogenous LTD4. |
| spellingShingle | Han, H Tian, R Neubauer, S Gaudron, P Hu, K Ertl, G Effects of LTD4 and its specific antagonist L-660,711 in isolated rat hearts with chronic myocardial infarction |
| title | Effects of LTD4 and its specific antagonist L-660,711 in isolated rat hearts with chronic myocardial infarction |
| title_full | Effects of LTD4 and its specific antagonist L-660,711 in isolated rat hearts with chronic myocardial infarction |
| title_fullStr | Effects of LTD4 and its specific antagonist L-660,711 in isolated rat hearts with chronic myocardial infarction |
| title_full_unstemmed | Effects of LTD4 and its specific antagonist L-660,711 in isolated rat hearts with chronic myocardial infarction |
| title_short | Effects of LTD4 and its specific antagonist L-660,711 in isolated rat hearts with chronic myocardial infarction |
| title_sort | effects of ltd4 and its specific antagonist l 660 711 in isolated rat hearts with chronic myocardial infarction |
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