The promiscuous MLL gene links chromosomal translocations to cellular differentiation and tumour tropism.
MLL is a promiscuous gene involved in a diversity of chromosomal fusions in haematological malignancies, usually resulting from chromosomal translocations. MLL-associated chromosomal rearrangements usually occur in tumours of specific haematological lineages, suggesting a crucial role for the MLL fu...
| Main Authors: | , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2002
|
| _version_ | 1826262874072285184 |
|---|---|
| author | Collins, E Rabbitts, T |
| author_facet | Collins, E Rabbitts, T |
| author_sort | Collins, E |
| collection | OXFORD |
| description | MLL is a promiscuous gene involved in a diversity of chromosomal fusions in haematological malignancies, usually resulting from chromosomal translocations. MLL-associated chromosomal rearrangements usually occur in tumours of specific haematological lineages, suggesting a crucial role for the MLL fusion partner in determining disease phenotype (or tumour tropism). The MLL gene is homologous to Drosophila trithorax, and is likewise involved in embryo pattern formation. Common themes linking several of the MLL partners include a possible involvement in embryo patterning via Hox gene regulation and chromatin remodelling. These findings reinforce the link between developmental regulation and chromosomal translocations, and indicate the role of chromosomal translocation in activating genes capable of determining tumour phenotype in leukaemias and sarcomas. |
| first_indexed | 2024-03-06T19:42:43Z |
| format | Journal article |
| id | oxford-uuid:2136c7d4-d04c-4826-bf39-57749369ff88 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:42:43Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:2136c7d4-d04c-4826-bf39-57749369ff882022-03-26T11:32:04ZThe promiscuous MLL gene links chromosomal translocations to cellular differentiation and tumour tropism.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2136c7d4-d04c-4826-bf39-57749369ff88EnglishSymplectic Elements at Oxford2002Collins, ERabbitts, TMLL is a promiscuous gene involved in a diversity of chromosomal fusions in haematological malignancies, usually resulting from chromosomal translocations. MLL-associated chromosomal rearrangements usually occur in tumours of specific haematological lineages, suggesting a crucial role for the MLL fusion partner in determining disease phenotype (or tumour tropism). The MLL gene is homologous to Drosophila trithorax, and is likewise involved in embryo pattern formation. Common themes linking several of the MLL partners include a possible involvement in embryo patterning via Hox gene regulation and chromatin remodelling. These findings reinforce the link between developmental regulation and chromosomal translocations, and indicate the role of chromosomal translocation in activating genes capable of determining tumour phenotype in leukaemias and sarcomas. |
| spellingShingle | Collins, E Rabbitts, T The promiscuous MLL gene links chromosomal translocations to cellular differentiation and tumour tropism. |
| title | The promiscuous MLL gene links chromosomal translocations to cellular differentiation and tumour tropism. |
| title_full | The promiscuous MLL gene links chromosomal translocations to cellular differentiation and tumour tropism. |
| title_fullStr | The promiscuous MLL gene links chromosomal translocations to cellular differentiation and tumour tropism. |
| title_full_unstemmed | The promiscuous MLL gene links chromosomal translocations to cellular differentiation and tumour tropism. |
| title_short | The promiscuous MLL gene links chromosomal translocations to cellular differentiation and tumour tropism. |
| title_sort | promiscuous mll gene links chromosomal translocations to cellular differentiation and tumour tropism |
| work_keys_str_mv | AT collinse thepromiscuousmllgenelinkschromosomaltranslocationstocellulardifferentiationandtumourtropism AT rabbittst thepromiscuousmllgenelinkschromosomaltranslocationstocellulardifferentiationandtumourtropism AT collinse promiscuousmllgenelinkschromosomaltranslocationstocellulardifferentiationandtumourtropism AT rabbittst promiscuousmllgenelinkschromosomaltranslocationstocellulardifferentiationandtumourtropism |