Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia.

Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia.

Show other versions (1)

UNLABELLED: Genetic lesions such as BCR-ABL1, E2A-PBX1, and MLL rearrangements (MLLr) are associated with unfavorable outcomes in adult B-cell precursor acute lymphoblastic leukemia (B-ALL). Leukemia oncoproteins may directly or indirectly disrupt cytosine methylation patterning to mediate the malig...

Full description

Bibliographic Details
Main Authors:	Geng, H, Brennan, S, Milne, T, Chen, W, Li, Y, Hurtz, C, Kweon, S, Zickl, L, Shojaee, S, Neuberg, D, Huang, C, Biswas, D, Xin, Y, Racevskis, J, Ketterling, R, Luger, S, Lazarus, H, Tallman, MS, Rowe, J, Litzow, MR, Guzman, M, Allis, C, Roeder, R, Müschen, M, Paietta, E
Format:	Journal article
Language:	English
Published:	2012

Similar Items

Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia
by: Geng, H, et al.
Published: (2012)

Integrative Genome Wide DNA Methylation and Gene Expression Analysis Reveals Biological and Clinical Insights In Adult Acute Lymphoblastic Leukemia
by: Geng, H, et al.
Published: (2010)

Integrative Genome-Wide DNA Methylation and Gene Expression Analysis Reveals Biological and Clinical Insights In Adult Acute Lymphoblastic Leukemia
by: Geng, H, et al.
Published: (2010)

Integrative Genome Wide DNA Methylation and Gene Expression Analysis Reveals Biological and Clinical Insights In Adult Acute Lymphoblastic Leukemia
by: Geng, H, et al.
Published: (2010)

Imatinib Significantly Enhances Long-Term Outcomes In Philadelphia Positive Acute Lymphoblastic Leukaemia; Final Results of the UKALLXII/ECOG2993 Trial
by: Fielding, A, et al.
Published: (2010)

Imatinib Significantly Enhances Long Term Outcomes In Philadelphia Positive Acute Lymphoblastic Leukaemia, Final Results of the UKALLXII/ECOG2993 Trial
by: Fielding, A, et al.
Published: (2010)

Imatinib Significantly Enhances Long Term Outcomes In Philadelphia Positive Acute Lymphoblastic Leukaemia, Final Results of the UKALLXII/ECOG2993 Trial
by: Fielding, A, et al.
Published: (2010)

T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993).
by: Marks, D, et al.
Published: (2009)

UKALLXII/ECOG2993: addition of imatinib to a standard treatment regimen enhances long-term outcomes in Philadelphia positive acute lymphoblastic leukemia.
by: Fielding, A, et al.
Published: (2014)

Delays in Post-Remission Chemotherapy for Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia are Associated with Inferior Outcomes in Patients who Undergo Allogeneic Transplant: An Analysis from ECOG 2993/MRC UK ALLXII.
by: Kumar, A, et al.
Published: (2016)

Epigenome-wide association study of acute lymphoblastic leukemia in children with Down syndrome
by: Li, S, et al.
Published: (2022)

Outcome of 1,229 Adult Philadelphia Chromosome Negative B Acute Lymphoblastic Leukemia (B-ALL) Patients (pts) From the International UKALLXII/E2993 Trial: No Difference In Results Between B Cell Immunophenotypic Subgroups
by: Lrrzow, MR, et al.
Published: (2010)

At three years, patients with acute lymphoblastic leukaemia are still at risk for relapse. Results of the international MRC UKALLXII/ECOG E2993 trial
by: Ganzel, C, et al.
Published: (2020)

Standard Consolidation/Maintenance Chemotherapy Is Consistently Superior to a Single Autologous Transplant for Adult Patients with Acute Lymphoblastic Leukemia: Results of the International ALL Trial (MRC UKALL XII/ECOG E2993).
by: Rowe, J, et al.
Published: (2008)

Outcomes in older adults with acute lymphoblastic leukaemia (ALL): results from the international MRC UKALL XII/ECOG2993 trial.
by: Sive, J, et al.
Published: (2012)

Inability to Tolerate Standard Therapy Is a Major Reason for Poor Outcome In Older Adults with Acute Lymphoblastic Leukemia (ALL) Results From the International MRC/ECOG Trial
by: Sive, J, et al.
Published: (2010)

Inability to Tolerate Standard Therapy Is a Major Reason for Poor Outcome In Older Adults with Acute Lymphoblastic Leukemia (ALL) Results From the International MRC/ECOG Trial
by: Sive, J, et al.
Published: (2010)

Inability to Tolerate Standard Therapy Is a Major Reason for Poor Outcome In Older Adults with Acute Lymphoblastic Leukemia (ALL): Results From the International MRC/ECOG Trial
by: Sive, J, et al.
Published: (2010)

Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study.
by: Fielding, A, et al.
Published: (2007)

Outcome in Philadelphia Chromosome Positive (Ph plus ) Adult ALL Patients (Pts) May Be More Determined by CD25 Expression Than by Ph Status Per Se
by: Paietta, E, et al.
Published: (2008)

Implications for the Use of Monoclonal Antibodies in Future Adult ALL Trials: Analysis of Antigen Expression in 505 B-Lineage (B-Lin) ALL Patients (pts) on the MRC UKALLXII/ECOG2993 Intergroup Trial.
by: Paietta, E, et al.
Published: (2008)

Karyotype is an independent prognostic factor in adult acute lymphoblastic leukaemia
by: Moorman, A, et al.
Published: (2007)

Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia
by: Moorman, A, et al.
Published: (2007)

Prospective outcome data on 267 unselected adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia confirms superiority of allogeneic transplantation over chemotherapy in the pre-imatinib era: results from the International ALL Trial MRC UKALLXII/ECOG2993.
by: Fielding, A, et al.
Published: (2009)

High hyperdiploidy among adolescents and adults with acute lymphoblastic leukaemia (ALL): cytogenetic features, clinical characteristics and outcome.
by: Chilton, L, et al.
Published: (2014)

High hyperdiploidy among adolescents and adults with acute lymphoblastic leukaemia (ALL): cytogenetic features, clinical characteristics and outcome
by: Chilton, L, et al.
Published: (2014)

High hyperdiploidy among adolescents and adults with acute lymphoblastic leukaemia (ALL): Cytogenetic features, clinical characteristics and outcome
by: Chilton, L, et al.
Published: (2014)

In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: final results of the International ALL Trial (MRC UKALL XII/ECOG E2993).
by: Goldstone, A, et al.
Published: (2008)

Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.
by: Biswas, D, et al.
Published: (2011)

Philadelphia chromosome plus ve patients with adult acute lymphoblastic leukaemia (ALL), early results from the international ALL trial (MRC UKALL-XII/ECOG E2993).
by: Goldstone, A, et al.
Published: (1999)

Outcome of 1,229 Adult Philadelphia Chromosome Negative B Acute Lyrnphoblastic Leukemia (B ALL) Patients (pts) From the International UKALLXII/E2993 Trial No Difference In Results Between B Cell Immuno phenotypic Subgroups
by: Lrrzow, MR, et al.
Published: (2010)

Outcome of 1,229 Adult Philadelphia Chromosome Negative B Acute Lyrnphoblastic Leukemia (B ALL) Patients (pts) From the International UKALLXII/E2993 Trial No Difference In Results Between B Cell Immuno phenotypic Subgroups
by: Lrrzow, MR, et al.
Published: (2010)

Does imatinib change the outcome in philapdelphia chromosome positive acute lympooblastic leukaemia in adults? Data from the UKALLXII/ECOG2993 study
by: Fielding, A, et al.
Published: (2007)

Central nervous system involvement in adult acute lymphoblastic leukemia at diagnosis: results from the international ALL trial MRC UKALL XII/ECOG E2993.
by: Lazarus, H, et al.
Published: (2006)

Mammalian comparative genomics and epigenomics
by: Mikkelsen, Tarjei Sigurd, 1978-
Published: (2010)

The epigenome : molecular hide and seek /
by: Beck, Stephen V., et al.
Published: (2003)

Induction therapy for adults with acute lymphoblastic leukemia (ALL): Results of nearly 1,400 patients from the international ALL trial (MRC UKALL XII/ECOG E2993).
by: Rowe, J, et al.
Published: (2003)

Correlation-based Linking of Epigenomic Regions to Target Genes in Bulk and Single Cell Epigenomic Data
by: James, Benjamin Thomas
Published: (2023)

Regulation of MLL1 H3K4 methyltransferase activity by its core components.
by: Dou, Y, et al.
Published: (2006)

Induction therapy for adults with acute lymphoblastic leukemia: results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993.
by: Rowe, J, et al.
Published: (2005)