Retinoic acid signaling in thymic epithelial cells regulates thymopoiesis
Despite the essential role of thymic epithelial cells (TEC) in T cell development, the signals regulating TEC differentiation and homeostasis remain incompletely understood. In this study, we show a key in vivo role for the vitamin A metabolite, retinoic acid (RA), in TEC homeostasis. In the absence...
Huvudupphovsmän: | Wendland, K, Niss, K, Kotarsky, K, Wu, N, White, A, Jendholm, J, Rivollier, A, Izarzugaza, J, Brunak, S, Holländer, G, Anderson, G, Sitnik, K, Agace, W |
---|---|
Materialtyp: | Journal article |
Språk: | English |
Publicerad: |
American Association of Immunologists
2018
|
Liknande verk
Liknande verk
-
Thymic epithelial cell support of thymopoiesis does not require Klotho
av: Xing, Y, et al.
Publicerad: (2018) -
T cell progenitor therapy–facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction
av: Smith, M, et al.
Publicerad: (2017) -
Thymus extracellular matrix-derived scaffolds support graft-resident thymopoiesis and long-term in vitro culture of adult thymic epithelial cells
av: Asnaghi, MA, et al.
Publicerad: (2021) -
LENTIVIRAL TRANSDUCTION OF PRIMARY ADULT MOUSE THYMIC EPITHELIAL CELLS TO CREATE CELLS COMPETENT TO SUPPORT REGULAR THYMOPOIESIS BOTH IN VITRO AND IN VIVO
av: Bosticardo, M, et al.
Publicerad: (2012) -
Flt3 ligand-receptor interaction is important for maintenance of early thymic progenitor numbers in steady-state thymopoiesis.
av: Kenins, L, et al.
Publicerad: (2010)