Retinoic acid signaling in thymic epithelial cells regulates thymopoiesis

Despite the essential role of thymic epithelial cells (TEC) in T cell development, the signals regulating TEC differentiation and homeostasis remain incompletely understood. In this study, we show a key in vivo role for the vitamin A metabolite, retinoic acid (RA), in TEC homeostasis. In the absence...

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Detalles Bibliográficos
Autores principales: Wendland, K, Niss, K, Kotarsky, K, Wu, N, White, A, Jendholm, J, Rivollier, A, Izarzugaza, J, Brunak, S, Holländer, G, Anderson, G, Sitnik, K, Agace, W
Formato: Journal article
Lenguaje:English
Publicado: American Association of Immunologists 2018