Eukaryotic domain evolution inferred from genome comparisons.
Comparative analyses of eukaryotic genomes are providing insights into the mode and tempo of domain family evolution. Gene duplication, the source of family expansion, far exceeds the rate of emergence of domains from non-coding sequence, and the rate of recruitment of domains into novel architectur...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2003
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| _version_ | 1797057954124398592 |
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| author | Copley, R Goodstadt, L Ponting, C |
| author_facet | Copley, R Goodstadt, L Ponting, C |
| author_sort | Copley, R |
| collection | OXFORD |
| description | Comparative analyses of eukaryotic genomes are providing insights into the mode and tempo of domain family evolution. Gene duplication, the source of family expansion, far exceeds the rate of emergence of domains from non-coding sequence, and the rate of recruitment of domains into novel architectures. Domain families that appear to be restricted to certain lineages are likely to be the result of gene duplication, coupled with rapid sequence diversification. If such families are evidence of past adaptation, then their functions must relate to the underlying mechanism of selection: competition among organisms. |
| first_indexed | 2024-03-06T19:43:42Z |
| format | Journal article |
| id | oxford-uuid:21881b8d-c985-46a9-bc72-bd4a5542523a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:43:42Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:21881b8d-c985-46a9-bc72-bd4a5542523a2022-03-26T11:34:00ZEukaryotic domain evolution inferred from genome comparisons.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:21881b8d-c985-46a9-bc72-bd4a5542523aEnglishSymplectic Elements at Oxford2003Copley, RGoodstadt, LPonting, CComparative analyses of eukaryotic genomes are providing insights into the mode and tempo of domain family evolution. Gene duplication, the source of family expansion, far exceeds the rate of emergence of domains from non-coding sequence, and the rate of recruitment of domains into novel architectures. Domain families that appear to be restricted to certain lineages are likely to be the result of gene duplication, coupled with rapid sequence diversification. If such families are evidence of past adaptation, then their functions must relate to the underlying mechanism of selection: competition among organisms. |
| spellingShingle | Copley, R Goodstadt, L Ponting, C Eukaryotic domain evolution inferred from genome comparisons. |
| title | Eukaryotic domain evolution inferred from genome comparisons. |
| title_full | Eukaryotic domain evolution inferred from genome comparisons. |
| title_fullStr | Eukaryotic domain evolution inferred from genome comparisons. |
| title_full_unstemmed | Eukaryotic domain evolution inferred from genome comparisons. |
| title_short | Eukaryotic domain evolution inferred from genome comparisons. |
| title_sort | eukaryotic domain evolution inferred from genome comparisons |
| work_keys_str_mv | AT copleyr eukaryoticdomainevolutioninferredfromgenomecomparisons AT goodstadtl eukaryoticdomainevolutioninferredfromgenomecomparisons AT pontingc eukaryoticdomainevolutioninferredfromgenomecomparisons |