Reduction of C X to CH2
The complete reduction of the carbonyl group of an aldehyde or ketone to a methylene/methyl group is generally achieved using the well-known Wolff-Kishner and Clemmensen reductions and these two transformations form the majority of the chapter. A range of useful procedures along with possible side r...
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Elsevier
2014
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| Summary: | The complete reduction of the carbonyl group of an aldehyde or ketone to a methylene/methyl group is generally achieved using the well-known Wolff-Kishner and Clemmensen reductions and these two transformations form the majority of the chapter. A range of useful procedures along with possible side reactions is presented; examples will be mainly taken from the recent literature. The use of ionic hydrogenation and metal-catalyzed hydrogenolysis, using predominantly aromatic ketones and aldehydes, is also presented. Other methods are briefly discussed. © 2014 Elsevier Ltd. All rights reserved. |
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