Hebbian activity-dependent plasticity in white matter
Synaptic plasticity is required for learning and follows Hebb’s rule, the computational principle underpinning associative learning. In recent years, a complementary type of brain plasticity has been identified in myelinated axons, which make up the majority of brain’s white matter. Like synaptic pl...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Cell Press
2022
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| _version_ | 1826310275194683392 |
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| author | Lazari, A Salvan, P Cottaar, M Papp, D Rushworth, MFS Johansen-Berg, H |
| author_facet | Lazari, A Salvan, P Cottaar, M Papp, D Rushworth, MFS Johansen-Berg, H |
| author_sort | Lazari, A |
| collection | OXFORD |
| description | Synaptic plasticity is required for learning and follows Hebb’s rule, the computational principle underpinning associative learning. In recent years, a complementary type of brain plasticity has been identified in myelinated axons, which make up the majority of brain’s white matter. Like synaptic plasticity, myelin plasticity is required for learning, but it is unclear whether it is Hebbian or whether it follows different rules. Here, we provide evidence that white matter plasticity operates following Hebb’s rule in humans. Across two experiments, we find that co-stimulating cortical areas to induce Hebbian plasticity leads to relative increases in cortical excitability and associated increases in a myelin marker within the stimulated fiber bundle. We conclude that Hebbian plasticity extends beyond synaptic changes and can be observed in human white matter fibers. |
| first_indexed | 2024-03-07T07:48:00Z |
| format | Journal article |
| id | oxford-uuid:21f5e36d-585a-4c28-8925-117ceb385648 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:48:00Z |
| publishDate | 2022 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:21f5e36d-585a-4c28-8925-117ceb3856482023-07-03T14:25:03ZHebbian activity-dependent plasticity in white matterJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:21f5e36d-585a-4c28-8925-117ceb385648EnglishSymplectic ElementsCell Press2022Lazari, ASalvan, PCottaar, MPapp, DRushworth, MFSJohansen-Berg, HSynaptic plasticity is required for learning and follows Hebb’s rule, the computational principle underpinning associative learning. In recent years, a complementary type of brain plasticity has been identified in myelinated axons, which make up the majority of brain’s white matter. Like synaptic plasticity, myelin plasticity is required for learning, but it is unclear whether it is Hebbian or whether it follows different rules. Here, we provide evidence that white matter plasticity operates following Hebb’s rule in humans. Across two experiments, we find that co-stimulating cortical areas to induce Hebbian plasticity leads to relative increases in cortical excitability and associated increases in a myelin marker within the stimulated fiber bundle. We conclude that Hebbian plasticity extends beyond synaptic changes and can be observed in human white matter fibers. |
| spellingShingle | Lazari, A Salvan, P Cottaar, M Papp, D Rushworth, MFS Johansen-Berg, H Hebbian activity-dependent plasticity in white matter |
| title | Hebbian activity-dependent plasticity in white matter |
| title_full | Hebbian activity-dependent plasticity in white matter |
| title_fullStr | Hebbian activity-dependent plasticity in white matter |
| title_full_unstemmed | Hebbian activity-dependent plasticity in white matter |
| title_short | Hebbian activity-dependent plasticity in white matter |
| title_sort | hebbian activity dependent plasticity in white matter |
| work_keys_str_mv | AT lazaria hebbianactivitydependentplasticityinwhitematter AT salvanp hebbianactivitydependentplasticityinwhitematter AT cottaarm hebbianactivitydependentplasticityinwhitematter AT pappd hebbianactivitydependentplasticityinwhitematter AT rushworthmfs hebbianactivitydependentplasticityinwhitematter AT johansenbergh hebbianactivitydependentplasticityinwhitematter |