Drug action at the 5-HT(1A) receptor in vivo: autoreceptor and postsynaptic receptor occupancy examined with PET and [carbonyl-(11)C]WAY-100635.

Serotonin(1A) (5-HT(1A)) receptors have been implicated in the pathophysiology and treatment of anxiety and depression and are a target for novel drug development. In this qualitative study, positron emission tomography (PET) and [carbonyl-(11)C]WAY-100635 were used to assess 5-HT(1A) autoreceptor a...

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Main Authors: Rabiner, E, Gunn, R, Wilkins, MR, Sargent, P, Mocaer, E, Sedman, E, Cowen, P, Grasby, P
格式: Journal article
语言:English
出版: 2000