Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4

Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4

To identify novel susceptibility loci for Crohn disease (CD), we undertook a genome-wide association study with more than 300,000 SNPs characterized in 547 patients and 928 controls. We found three chromosome regions that provided evidence of disease association with p-values between 10−6 and 10−9....

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Main Authors: Libioulle, C, Louis, E, Hansoul, S, Sandor, C, Farnir, F, Franchimont, D, Vermeire, S, Dewit, O, de Vos, M, Dixon, A, Demarche, B, Gut, I, Heath, S, Foglio, M, Liang, L, Laukens, D, Mni, M, Zelenika, D, Gossum, A, Rutgeerts, P, Belaiche, J, Lathrop, M, Georges, M
Format: Journal article
Published: Public Library of Science 2007

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