Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels-Alderase

Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels-Alderase

Prenylated indole alkaloids such as the calmodulin-inhibitory malbrancheamides and anthelmintic paraherquamides possess great structural diversity and pharmaceutical utility. Here, we report complete elucidation of the malbrancheamide biosynthetic pathway accomplished through complementary approache...

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Bibliographic Details
Main Authors:	Dan, Q, Newmister, SA, Klas, KR, Fraley, AE, McAfoos, TJ, Somoza, AD, Sunderhaus, JD, Ye, Y, Shende, VV, Yu, F, Sanders, JN, Brown, WC, Zhao, L, Paton, RS, Houk, KN, Smith, JL, Sherman, DH, Williams, RM
Format:	Journal article
Language:	English
Published:	Nature Research 2019

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