General and specific immunosuppression caused by antiviral T-cell responses.
Immunosuppression caused by the non-cytopathic lymphocytic choriomeningitis virus (LCMV) (an RNA virus) is mediated by antiviral cytotoxic T cells that destroy LCMV-infected cells, also of the immune system. While this immunopathological destruction of antigen-presenting cells, macrophages and folli...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1999
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| _version_ | 1826263107197992960 |
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| author | Zinkernagel, R Planz, O Ehl, S Battegay, M Odermatt, B Klenerman, P Hengartner, H |
| author_facet | Zinkernagel, R Planz, O Ehl, S Battegay, M Odermatt, B Klenerman, P Hengartner, H |
| author_sort | Zinkernagel, R |
| collection | OXFORD |
| description | Immunosuppression caused by the non-cytopathic lymphocytic choriomeningitis virus (LCMV) (an RNA virus) is mediated by antiviral cytotoxic T cells that destroy LCMV-infected cells, also of the immune system. While this immunopathological destruction of antigen-presenting cells, macrophages and follicular dendritic cells and of some CD4+ T cells causes general immunosuppression and impairs immune response to third party antigens, it also enhances exhaustion/deletion of LCMV-specific CD8+ T-cell responses. LCMV seems in addition to infect neutralizing antibody-producing B cells via the specific receptor; immunopathological LCMV specific CD8+ T-cell-mediated elimination of these infected B cells (but not of uninfected internal virus antigen-specific B cells) causes a highly specific immunosuppression that delays neutralizing antibody responses and thereby enhances virus persistence. Both generalized and specific immunosuppression by CD8+ T-cell-mediated immunopathology may be involved in human infections with HIV, hepatitis B virus or hepatitis C virus. |
| first_indexed | 2024-03-06T19:46:26Z |
| format | Journal article |
| id | oxford-uuid:22739be3-0a4f-41c7-9c18-6de87ab59d0a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:46:26Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:22739be3-0a4f-41c7-9c18-6de87ab59d0a2022-03-26T11:38:55ZGeneral and specific immunosuppression caused by antiviral T-cell responses.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:22739be3-0a4f-41c7-9c18-6de87ab59d0aEnglishSymplectic Elements at Oxford1999Zinkernagel, RPlanz, OEhl, SBattegay, MOdermatt, BKlenerman, PHengartner, HImmunosuppression caused by the non-cytopathic lymphocytic choriomeningitis virus (LCMV) (an RNA virus) is mediated by antiviral cytotoxic T cells that destroy LCMV-infected cells, also of the immune system. While this immunopathological destruction of antigen-presenting cells, macrophages and follicular dendritic cells and of some CD4+ T cells causes general immunosuppression and impairs immune response to third party antigens, it also enhances exhaustion/deletion of LCMV-specific CD8+ T-cell responses. LCMV seems in addition to infect neutralizing antibody-producing B cells via the specific receptor; immunopathological LCMV specific CD8+ T-cell-mediated elimination of these infected B cells (but not of uninfected internal virus antigen-specific B cells) causes a highly specific immunosuppression that delays neutralizing antibody responses and thereby enhances virus persistence. Both generalized and specific immunosuppression by CD8+ T-cell-mediated immunopathology may be involved in human infections with HIV, hepatitis B virus or hepatitis C virus. |
| spellingShingle | Zinkernagel, R Planz, O Ehl, S Battegay, M Odermatt, B Klenerman, P Hengartner, H General and specific immunosuppression caused by antiviral T-cell responses. |
| title | General and specific immunosuppression caused by antiviral T-cell responses. |
| title_full | General and specific immunosuppression caused by antiviral T-cell responses. |
| title_fullStr | General and specific immunosuppression caused by antiviral T-cell responses. |
| title_full_unstemmed | General and specific immunosuppression caused by antiviral T-cell responses. |
| title_short | General and specific immunosuppression caused by antiviral T-cell responses. |
| title_sort | general and specific immunosuppression caused by antiviral t cell responses |
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