Tau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics
Understanding the role of Tau protein aggregation in the pathogenesis of Alzheimer's disease is critical for the development of new Tau-based therapeutic strategies to slow or prevent dementia. We tested the hypothesis that Tau pathology is associated with functional organization of widespread...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2020
|
| _version_ | 1826263129336578048 |
|---|---|
| author | Kocagoncu, E Quinn, A Firouzian, A Cooper, E Greve, A Gunn, R Green, G Woolrich, MW Henson, RN Lovestone, S Deep and Frequent Phenotyping study team Rowe, JB |
| author_facet | Kocagoncu, E Quinn, A Firouzian, A Cooper, E Greve, A Gunn, R Green, G Woolrich, MW Henson, RN Lovestone, S Deep and Frequent Phenotyping study team Rowe, JB |
| author_sort | Kocagoncu, E |
| collection | OXFORD |
| description | Understanding the role of Tau protein aggregation in the pathogenesis of Alzheimer's disease is critical for the development of new Tau-based therapeutic strategies to slow or prevent dementia. We tested the hypothesis that Tau pathology is associated with functional organization of widespread neurophysiological networks. We used electro-magnetoencephalography with [18F]AV-1451 PET scanning to quantify Tau-dependent network changes. Using a graph theoretical approach to brain connectivity, we quantified nodal measures of functional segregation, centrality, and the efficiency of information transfer and tested them against levels of [18F]AV-1451. Higher Tau burden in early Alzheimer's disease was associated with a shift away from the optimal small-world organization and a more fragmented network in the beta and gamma bands, whereby parieto-occipital areas were disconnected from the anterior parts of the network. Similarly, higher Tau burden was associated with decreases in both local and global efficiency, especially in the gamma band. The results support the translational development of neurophysiological “signatures” of Alzheimer's disease, to understand disease mechanisms in humans and facilitate experimental medicine studies. |
| first_indexed | 2024-03-06T19:46:48Z |
| format | Journal article |
| id | oxford-uuid:2293a470-643a-434f-b92a-761af1b682c4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:46:48Z |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:2293a470-643a-434f-b92a-761af1b682c42022-03-26T11:39:36ZTau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamicsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2293a470-643a-434f-b92a-761af1b682c4EnglishSymplectic ElementsElsevier2020Kocagoncu, EQuinn, AFirouzian, ACooper, EGreve, AGunn, RGreen, GWoolrich, MWHenson, RNLovestone, SDeep and Frequent Phenotyping study teamRowe, JBUnderstanding the role of Tau protein aggregation in the pathogenesis of Alzheimer's disease is critical for the development of new Tau-based therapeutic strategies to slow or prevent dementia. We tested the hypothesis that Tau pathology is associated with functional organization of widespread neurophysiological networks. We used electro-magnetoencephalography with [18F]AV-1451 PET scanning to quantify Tau-dependent network changes. Using a graph theoretical approach to brain connectivity, we quantified nodal measures of functional segregation, centrality, and the efficiency of information transfer and tested them against levels of [18F]AV-1451. Higher Tau burden in early Alzheimer's disease was associated with a shift away from the optimal small-world organization and a more fragmented network in the beta and gamma bands, whereby parieto-occipital areas were disconnected from the anterior parts of the network. Similarly, higher Tau burden was associated with decreases in both local and global efficiency, especially in the gamma band. The results support the translational development of neurophysiological “signatures” of Alzheimer's disease, to understand disease mechanisms in humans and facilitate experimental medicine studies. |
| spellingShingle | Kocagoncu, E Quinn, A Firouzian, A Cooper, E Greve, A Gunn, R Green, G Woolrich, MW Henson, RN Lovestone, S Deep and Frequent Phenotyping study team Rowe, JB Tau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics |
| title | Tau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics |
| title_full | Tau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics |
| title_fullStr | Tau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics |
| title_full_unstemmed | Tau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics |
| title_short | Tau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics |
| title_sort | tau pathology in early alzheimer s disease is linked to selective disruptions in neurophysiological network dynamics |
| work_keys_str_mv | AT kocagoncue taupathologyinearlyalzheimersdiseaseislinkedtoselectivedisruptionsinneurophysiologicalnetworkdynamics AT quinna taupathologyinearlyalzheimersdiseaseislinkedtoselectivedisruptionsinneurophysiologicalnetworkdynamics AT firouziana taupathologyinearlyalzheimersdiseaseislinkedtoselectivedisruptionsinneurophysiologicalnetworkdynamics AT coopere taupathologyinearlyalzheimersdiseaseislinkedtoselectivedisruptionsinneurophysiologicalnetworkdynamics AT grevea taupathologyinearlyalzheimersdiseaseislinkedtoselectivedisruptionsinneurophysiologicalnetworkdynamics AT gunnr taupathologyinearlyalzheimersdiseaseislinkedtoselectivedisruptionsinneurophysiologicalnetworkdynamics AT greeng taupathologyinearlyalzheimersdiseaseislinkedtoselectivedisruptionsinneurophysiologicalnetworkdynamics AT woolrichmw taupathologyinearlyalzheimersdiseaseislinkedtoselectivedisruptionsinneurophysiologicalnetworkdynamics AT hensonrn taupathologyinearlyalzheimersdiseaseislinkedtoselectivedisruptionsinneurophysiologicalnetworkdynamics AT lovestones taupathologyinearlyalzheimersdiseaseislinkedtoselectivedisruptionsinneurophysiologicalnetworkdynamics AT deepandfrequentphenotypingstudyteam taupathologyinearlyalzheimersdiseaseislinkedtoselectivedisruptionsinneurophysiologicalnetworkdynamics AT rowejb taupathologyinearlyalzheimersdiseaseislinkedtoselectivedisruptionsinneurophysiologicalnetworkdynamics |