Nano-particle vaccination combined with TLR-7 and -9 ligands triggers memory and effector CD8⁺ T-cell responses in melanoma patients.

Nano-particle vaccination combined with TLR-7 and -9 ligands triggers memory and effector CD8⁺ T-cell responses in melanoma patients.

Optimal vaccine strategies must be identified for improving T-cell vaccination against infectious and malignant diseases. MelQbG10 is a virus-like nano-particle loaded with A-type CpG-oligonucleotides (CpG-ODN) and coupled to peptide(16-35) derived from Melan-A/MART-1. In this phase IIa clinical st...

书目详细资料
Main Authors:	Goldinger, S, Dummer, R, Baumgaertner, P, Mihic-Probst, D, Schwarz, K, Hammann-Haenni, A, Willers, J, Geldhof, C, Prior, J, Kündig, T, Michielin, O, Bachmann, M, Speiser, D
格式:	Journal article
语言:	English
出版:	2012

相似书籍

Memory and effector CD8 T-cell responses after nanoparticle vaccination of melanoma patients.
由: Speiser, D, et al.
出版: (2010)

TLR9- and TLR7-enhanced CD8(+) T cell responses are suppressed by TLR2-ligands
由: Schwarz, K, et al.
出版: (2007)

The novel TLR-9 agonist QbG10 shows clinical efficacy in persistent allergic asthma.
由: Beeh, K, et al.
出版: (2013)

Virus-like particles induce robust human T-helper cell responses.
由: Braun, M, et al.
出版: (2012)

Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests the mechanism for TCR antagonism.
由: Bachmann, M, et al.
出版: (1998)

The updated Swiss guidelines 2016 for the treatment and follow-up of cutaneous melanoma
由: Reinhard Dummer, et al.
出版: (2016-02-01)

Similar ligand densities required for restimulation and effector function of cytotoxic T cells.
由: Oxenius, A, et al.
出版: (1997)

Peripheral T cells in mice lacking p56lck do not express significant antiviral effector functions.
由: Molina, T, et al.
出版: (1993)

Assessment of clinical efficacy of CYT003-QbG10 in patients with allergic rhinoconjunctivitis: a phase IIb study.
由: Klimek, L, et al.
出版: (2011)

Altered peptide ligands trigger perforin- rather than Fas-dependent cell lysis.
由: Bachmann, M, et al.
出版: (1997)

Tumor cell plasticity and angiogenesis in human melanomas.
由: Daniela Mihic-Probst, et al.
出版: (2012-01-01)

pDC Activation by TLR7/8 Ligand CL097 Compared to TLR7 Ligand IMQ or TLR9 Ligand CpG
由: Jing Wu, et al.
出版: (2019-01-01)

Limited in vivo reactivity of polyclonal effector cytotoxic T cells towards altered peptide ligands.
由: Bättig, P, et al.
出版: (2005)

The C-terminal extension landscape of naturally presented HLA-I ligands
由: Guillaume, P, et al.
出版: (2018)

Nectin Family Ligands Trigger Immune Effector Functions in Health and Autoimmunity
由: Doryssa Hermans, et al.
出版: (2023-03-01)

Detecting BRAF Mutations in Formalin-Fixed Melanoma: Experiences with TwoState-of-the-Art Techniques
由: Nicola L. Schoenewolf, et al.
出版: (2012-06-01)

Maintenance of homeostasis by TLR4 ligands
由: Masataka Oda, et al.
出版: (2024-04-01)

T cell responses are governed by avidity and co-stimulatory thresholds.
由: Bachmann, M, et al.
出版: (1996)

The Ligands for Human IgG and Their Effector Functions
由: Steven W. de Taeye, et al.
出版: (2019-04-01)

Low Avidity T Cells Do Not Hinder High Avidity T Cell Responses Against Melanoma
由: Kalliopi Ioannidou, et al.
出版: (2019-09-01)

CD28-negative cytolytic effector T cells frequently express NK receptors and are present at variable proportions in circulating lymphocytes from healthy donors and melanoma patients.
由: Speiser, D, et al.
出版: (1999)

Fonsecaeapedrosoi Conidia and Hyphae Activate Neutrophils Distinctly: Requirement of TLR-2 and TLR-4 in Neutrophil Effector Functions
由: Leandro Carvalho Dantas Breda, et al.
出版: (2020-10-01)

Evolving impact of long-term survival results on metastatic melanoma treatment
由: Olivier Michielin, et al.
出版: (2020-10-01)

Expression of MAGE-C1/CT7 and MAGE-C2/CT10 predicts lymph node metastasis in melanoma patients.
由: Alessandra Curioni-Fontecedro, et al.
出版: (2011-01-01)

Toll-Like Receptor Ligand-Induced Liver Injury in D-Galactosamine-Sensitized Mice: Differences between TLR7/8 and TLR9 Ligands, Cytokine Patterns, and Cross-Tolerance Induction by TLR2 Ligand Pretreatment
由: Reiko Seki
出版: (2017-01-01)

Rationally Designed TLR4 Ligands for Vaccine Adjuvant Discovery
由: Kelsey A. Gregg, et al.
出版: (2017-07-01)

TLR ligands induce antiviral responses in chicken macrophages.
由: Neda Barjesteh, et al.
出版: (2014-01-01)

Malignancy Rate of Indeterminate Findings on FDG-PET/CT in Cutaneous Melanoma Patients
由: Ken Kudura, et al.
出版: (2021-05-01)

T-cell-independent antiviral B cell responses in CD45-deficient mice.
由: Bachmann, M, et al.
出版: (1997)

A Highly Sensitive Cell-Based TLR Reporter Platform for the Specific Detection of Bacterial TLR Ligands
由: Katharina Radakovics, et al.
出版: (2022-01-01)

Combinations of TLR Ligands: A Promising Approach in Cancer Immunotherapy
由: Saskia Stier, et al.
出版: (2013-01-01)

Evaluation of the Interplay between the ADAR Editome and Immunotherapy in Melanoma
由: Marina Tusup, et al.
出版: (2021-01-01)

Combined TLR7/8 and TLR9 ligands potentiate the activity of a Schistosoma japonicum DNA vaccine.
由: Xuefeng Wang, et al.
出版: (2013-01-01)

Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding.
由: Joseph A Newman, et al.
出版: (2016-01-01)

Analysis of BRAF and NRAS Mutation Status in Advanced Melanoma Patients Treated with Anti-CTLA-4 Antibodies: Association with Overall Survival?
由: Joanna Mangana, et al.
出版: (2015-01-01)

SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens.
由: Mukhopadhyay, S, et al.
出版: (2011)

CXCR3 Ligands in Cancer and Autoimmunity, Chemoattraction of Effector T Cells, and Beyond
由: Nathan Karin
出版: (2020-05-01)

Very Late Antigen-1 marks functional tumor-resident CD8 T cells and correlates with survival of melanoma patients
由: Timothy Murray, et al.
出版: (2016-12-01)

TLR-Agonist Mediated Enhancement of Antibody-Dependent Effector Functions as Strategy For an HIV-1 Cure
由: Caroline Thue Hvilsom, et al.
出版: (2021-09-01)

Prediction of cross-recognition of peptide-HLA A2 by Melan-A-specific cytotoxic T lymphocytes using three-dimensional quantitative structure-activity relationships.
由: Theres Fagerberg, et al.
出版: (2013-01-01)