A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11.
A novel testis-expressed Zn finger gene (ZNF76) was identified by screening cDNA libraries with cosmids derived from 6p21. ZNF76 is a member of the GLI-Krüppel family of DNA binding proteins. It is conserved in mouse where transcription in testis is initiated at Day 20 after birth. The mouse tcp-11...
| Κύριοι συγγραφείς: | , , , , , , , |
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| Μορφή: | Journal article |
| Γλώσσα: | English |
| Έκδοση: |
1992
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| _version_ | 1826263152081240064 |
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| author | Ragoussis, I Senger, G Mockridge, I Sanseau, P Ruddy, S Dudley, K Sheer, D Trowsdale, J |
| author_facet | Ragoussis, I Senger, G Mockridge, I Sanseau, P Ruddy, S Dudley, K Sheer, D Trowsdale, J |
| author_sort | Ragoussis, I |
| collection | OXFORD |
| description | A novel testis-expressed Zn finger gene (ZNF76) was identified by screening cDNA libraries with cosmids derived from 6p21. ZNF76 is a member of the GLI-Krüppel family of DNA binding proteins. It is conserved in mouse where transcription in testis is initiated at Day 20 after birth. The mouse tcp-11 gene is located in the distal inversion of the t-complex and is developmentally regulated in the same manner as ZNF76. The human homolog of tcp-11 was isolated to allow a precise chromosomal localization. By using a combination of somatic cell hybrids, radiation hybrids, metaphase and interphase fluorescent in situ hybridization, and pulsed-field gel electrophoresis, we mapped the two genes to the 6p21.2 to 6p21.3 region and linked them to each other within 300 kb of DNA, approximately 2 Mb centromeric to the major histocompatibility complex. |
| first_indexed | 2024-03-06T19:47:09Z |
| format | Journal article |
| id | oxford-uuid:22b39ef6-f60d-4d9c-a8ae-29755a283111 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:47:09Z |
| publishDate | 1992 |
| record_format | dspace |
| spelling | oxford-uuid:22b39ef6-f60d-4d9c-a8ae-29755a2831112022-03-26T11:40:12ZA testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:22b39ef6-f60d-4d9c-a8ae-29755a283111EnglishSymplectic Elements at Oxford1992Ragoussis, ISenger, GMockridge, ISanseau, PRuddy, SDudley, KSheer, DTrowsdale, JA novel testis-expressed Zn finger gene (ZNF76) was identified by screening cDNA libraries with cosmids derived from 6p21. ZNF76 is a member of the GLI-Krüppel family of DNA binding proteins. It is conserved in mouse where transcription in testis is initiated at Day 20 after birth. The mouse tcp-11 gene is located in the distal inversion of the t-complex and is developmentally regulated in the same manner as ZNF76. The human homolog of tcp-11 was isolated to allow a precise chromosomal localization. By using a combination of somatic cell hybrids, radiation hybrids, metaphase and interphase fluorescent in situ hybridization, and pulsed-field gel electrophoresis, we mapped the two genes to the 6p21.2 to 6p21.3 region and linked them to each other within 300 kb of DNA, approximately 2 Mb centromeric to the major histocompatibility complex. |
| spellingShingle | Ragoussis, I Senger, G Mockridge, I Sanseau, P Ruddy, S Dudley, K Sheer, D Trowsdale, J A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11. |
| title | A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11. |
| title_full | A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11. |
| title_fullStr | A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11. |
| title_full_unstemmed | A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11. |
| title_short | A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11. |
| title_sort | testis expressed zn finger gene znf76 in human 6p21 3 centromeric to the mhc is closely linked to the human homolog of the t complex gene tcp 11 |
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