Fractional anisotropy in the posterior limb of the internal capsule and prognosis in amyotrophic lateral sclerosis.
OBJECTIVE: To explore the value of diffusion tensor imaging applied to those specific cerebral white matter tracts consistently involved pathologically in amyotrophic lateral sclerosis as a source of prognostic biomarkers. DESIGN: Baseline clinical assessment and 3-T diffusion tensor imaging, repeat...
| المؤلفون الرئيسيون: | , , , , , , |
|---|---|
| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
2012
|
| _version_ | 1826263157130133504 |
|---|---|
| author | Menke, R Abraham, I Thiel, C Filippini, N Knight, S Talbot, K Turner, M |
| author_facet | Menke, R Abraham, I Thiel, C Filippini, N Knight, S Talbot, K Turner, M |
| author_sort | Menke, R |
| collection | OXFORD |
| description | OBJECTIVE: To explore the value of diffusion tensor imaging applied to those specific cerebral white matter tracts consistently involved pathologically in amyotrophic lateral sclerosis as a source of prognostic biomarkers. DESIGN: Baseline clinical assessment and 3-T diffusion tensor imaging, repeated after approximately 6 months.Tract-based spatial statistics were used to assess voxel wise correlations of just the baseline diffusion tensor imaging indices with the progression rate (change in disability score/time interval) within the corticospinal tract and corpus callosum. PATIENTS: The study involved 21 patients with amyotrophic lateral sclerosis and 3 patients with primary lateral sclerosis. RESULTS: Correlation was observed between fractional anisotropy and progression rate for a region of the corticospinal tract spanning the posterior limb of the internal capsule, with a left hemisphere emphasis. Posterior limb of the internal capsule fractional anisotropy showed potential to distinguish those patients with rapid progression. Axial diffusivity significantly increased in this region in a paired t test analysis of baseline and follow-up diffusion tensor imaging, in keeping with axonal damage.No correlations were noted for the corpus callosum. CONCLUSIONS: Posterior limb of the internal capsule fractional anisotropy is a candidate prognostic marker in amyotrophic lateral sclerosis, with potential to identify incident cases with more rapid progression. |
| first_indexed | 2024-03-06T19:47:14Z |
| format | Journal article |
| id | oxford-uuid:22b9b51f-e08c-43d6-845b-bd1b63754661 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:47:14Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:22b9b51f-e08c-43d6-845b-bd1b637546612022-03-26T11:40:20ZFractional anisotropy in the posterior limb of the internal capsule and prognosis in amyotrophic lateral sclerosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:22b9b51f-e08c-43d6-845b-bd1b63754661EnglishSymplectic Elements at Oxford2012Menke, RAbraham, IThiel, CFilippini, NKnight, STalbot, KTurner, MOBJECTIVE: To explore the value of diffusion tensor imaging applied to those specific cerebral white matter tracts consistently involved pathologically in amyotrophic lateral sclerosis as a source of prognostic biomarkers. DESIGN: Baseline clinical assessment and 3-T diffusion tensor imaging, repeated after approximately 6 months.Tract-based spatial statistics were used to assess voxel wise correlations of just the baseline diffusion tensor imaging indices with the progression rate (change in disability score/time interval) within the corticospinal tract and corpus callosum. PATIENTS: The study involved 21 patients with amyotrophic lateral sclerosis and 3 patients with primary lateral sclerosis. RESULTS: Correlation was observed between fractional anisotropy and progression rate for a region of the corticospinal tract spanning the posterior limb of the internal capsule, with a left hemisphere emphasis. Posterior limb of the internal capsule fractional anisotropy showed potential to distinguish those patients with rapid progression. Axial diffusivity significantly increased in this region in a paired t test analysis of baseline and follow-up diffusion tensor imaging, in keeping with axonal damage.No correlations were noted for the corpus callosum. CONCLUSIONS: Posterior limb of the internal capsule fractional anisotropy is a candidate prognostic marker in amyotrophic lateral sclerosis, with potential to identify incident cases with more rapid progression. |
| spellingShingle | Menke, R Abraham, I Thiel, C Filippini, N Knight, S Talbot, K Turner, M Fractional anisotropy in the posterior limb of the internal capsule and prognosis in amyotrophic lateral sclerosis. |
| title | Fractional anisotropy in the posterior limb of the internal capsule and prognosis in amyotrophic lateral sclerosis. |
| title_full | Fractional anisotropy in the posterior limb of the internal capsule and prognosis in amyotrophic lateral sclerosis. |
| title_fullStr | Fractional anisotropy in the posterior limb of the internal capsule and prognosis in amyotrophic lateral sclerosis. |
| title_full_unstemmed | Fractional anisotropy in the posterior limb of the internal capsule and prognosis in amyotrophic lateral sclerosis. |
| title_short | Fractional anisotropy in the posterior limb of the internal capsule and prognosis in amyotrophic lateral sclerosis. |
| title_sort | fractional anisotropy in the posterior limb of the internal capsule and prognosis in amyotrophic lateral sclerosis |
| work_keys_str_mv | AT menker fractionalanisotropyintheposteriorlimboftheinternalcapsuleandprognosisinamyotrophiclateralsclerosis AT abrahami fractionalanisotropyintheposteriorlimboftheinternalcapsuleandprognosisinamyotrophiclateralsclerosis AT thielc fractionalanisotropyintheposteriorlimboftheinternalcapsuleandprognosisinamyotrophiclateralsclerosis AT filippinin fractionalanisotropyintheposteriorlimboftheinternalcapsuleandprognosisinamyotrophiclateralsclerosis AT knights fractionalanisotropyintheposteriorlimboftheinternalcapsuleandprognosisinamyotrophiclateralsclerosis AT talbotk fractionalanisotropyintheposteriorlimboftheinternalcapsuleandprognosisinamyotrophiclateralsclerosis AT turnerm fractionalanisotropyintheposteriorlimboftheinternalcapsuleandprognosisinamyotrophiclateralsclerosis |