Ex vivo characterization of early secretory antigenic target 6–specific T cells at sites of active disease in pleural tuberculosis

Ex vivo characterization of early secretory antigenic target 6–specific T cells at sites of active disease in pleural tuberculosis

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Presence of early secretory antigenic target-6 (ESAT-6)—specific, interferon-γ—secreting T cells in blood accurately marks tuberculosis infection. In tuberculous pleural effusions from 10 patients with tuberculosis, these cells were concentrated a mean of 15-fold (standard deviation, ±6-fold), relat...

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Bibliographic Details
Main Authors: Wilkinson, K, Wilkinson, R, Pathan, A, Ewer, K, Prakash, M, Klenerman, P, Maskell, N, Davies, R, Pasvol, G, Lalvani, A
Format: Conference item
Published: Oxford University Press 2005
Description
Summary:Presence of early secretory antigenic target-6 (ESAT-6)—specific, interferon-γ—secreting T cells in blood accurately marks tuberculosis infection. In tuberculous pleural effusions from 10 patients with tuberculosis, these cells were concentrated a mean of 15-fold (standard deviation, ±6-fold), relative to their level in peripheral blood (P = .014), and displayed rapid effector function. Such cells were absent in 8 control patients with nontuberculous pleural disease. The recruitment of ESAT-6—specific T cells to inflamed tuberculous tissue demonstrates their function in vivo and suggests a novel way to diagnose tuberculous pleuritis.

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