RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.

RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.

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Pancreatic β-cell dysfunction and death are central in the pathogenesis of type 2 diabetes (T2D). Saturated fatty acids cause β-cell failure and contribute to diabetes development in genetically predisposed individuals. Here we used RNA sequencing to map transcripts expressed in five palmitate-treat...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Cnop, M, Abdulkarim, B, Bottu, G, Cunha, D, Igoillo-Esteve, M, Masini, M, Turatsinze, J, Griebel, T, Villate, O, Santin, I, Bugliani, M, Ladriere, L, Marselli, L, McCarthy, M, Marchetti, P, Sammeth, M, Eizirik, D
التنسيق: Journal article
اللغة:English
منشور في: American Diabetes Association Inc. 2014

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