RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.

RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.

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Pancreatic β-cell dysfunction and death are central in the pathogenesis of type 2 diabetes (T2D). Saturated fatty acids cause β-cell failure and contribute to diabetes development in genetically predisposed individuals. Here we used RNA sequencing to map transcripts expressed in five palmitate-treat...

Bibliografske podrobnosti
Main Authors:	Cnop, M, Abdulkarim, B, Bottu, G, Cunha, D, Igoillo-Esteve, M, Masini, M, Turatsinze, J, Griebel, T, Villate, O, Santin, I, Bugliani, M, Ladriere, L, Marselli, L, McCarthy, M, Marchetti, P, Sammeth, M, Eizirik, D
Format:	Journal article
Jezik:	English
Izdano:	American Diabetes Association Inc. 2014

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