Qa-1(b)-dependent modulation of dendritic cell and NK cell cross-talk in vivo.
Dendritic cells (DC) trigger activation and IFN-gamma release by NK cells in lymphoid tissues, a process important for the polarization of Th1 responses. Little is known about the molecular signals that regulate DC-induced NK cell IFN-gamma synthesis. In this study, we analyzed whether the interacti...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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| _version_ | 1797058223505670144 |
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| author | Colmenero, P Zhang, A Qian, T Lu, L Cantor, H Söderström, K Engleman, E |
| author_facet | Colmenero, P Zhang, A Qian, T Lu, L Cantor, H Söderström, K Engleman, E |
| author_sort | Colmenero, P |
| collection | OXFORD |
| description | Dendritic cells (DC) trigger activation and IFN-gamma release by NK cells in lymphoid tissues, a process important for the polarization of Th1 responses. Little is known about the molecular signals that regulate DC-induced NK cell IFN-gamma synthesis. In this study, we analyzed whether the interaction between Qa-1(b) expressed on DC and its CD94/NKG2A receptor on NK cells affects this process. Activation of DC using CpG-oligodeoxynucleotides in Qa-1(b)-deficient mice, or transfer of CpG-oligodeoxynucleotide-activated Qa-1(b)-deficient DC into wild-type mice, resulted in dramatically increased IFN-gamma production by NK cells, as compared with that induced by Qa-1(b)-expressing DC. Masking the CD94/NKG2A inhibitory receptor on NK cells in wild-type mice similarly enhanced the IFN-gamma response of these cells to Qa-1(b)-expressing DC. Furthermore, NK cells from CD94/NKG2A-deficient mice displayed higher IFN-gamma production upon DC stimulation. These results demonstrate that Qa-1(b) is critically involved in regulating IFN-gamma synthesis by NK cells in vivo through its interaction with CD94/NKG2A inhibitory receptors. This receptor-ligand interaction may be essential to prevent unabated cytokine production by NK cells during an inflammatory response. |
| first_indexed | 2024-03-06T19:47:29Z |
| format | Journal article |
| id | oxford-uuid:22d1cdd2-b7d5-4b53-8b5f-42a5e88f1894 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:47:29Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:22d1cdd2-b7d5-4b53-8b5f-42a5e88f18942022-03-26T11:40:47ZQa-1(b)-dependent modulation of dendritic cell and NK cell cross-talk in vivo.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:22d1cdd2-b7d5-4b53-8b5f-42a5e88f1894EnglishSymplectic Elements at Oxford2007Colmenero, PZhang, AQian, TLu, LCantor, HSöderström, KEngleman, EDendritic cells (DC) trigger activation and IFN-gamma release by NK cells in lymphoid tissues, a process important for the polarization of Th1 responses. Little is known about the molecular signals that regulate DC-induced NK cell IFN-gamma synthesis. In this study, we analyzed whether the interaction between Qa-1(b) expressed on DC and its CD94/NKG2A receptor on NK cells affects this process. Activation of DC using CpG-oligodeoxynucleotides in Qa-1(b)-deficient mice, or transfer of CpG-oligodeoxynucleotide-activated Qa-1(b)-deficient DC into wild-type mice, resulted in dramatically increased IFN-gamma production by NK cells, as compared with that induced by Qa-1(b)-expressing DC. Masking the CD94/NKG2A inhibitory receptor on NK cells in wild-type mice similarly enhanced the IFN-gamma response of these cells to Qa-1(b)-expressing DC. Furthermore, NK cells from CD94/NKG2A-deficient mice displayed higher IFN-gamma production upon DC stimulation. These results demonstrate that Qa-1(b) is critically involved in regulating IFN-gamma synthesis by NK cells in vivo through its interaction with CD94/NKG2A inhibitory receptors. This receptor-ligand interaction may be essential to prevent unabated cytokine production by NK cells during an inflammatory response. |
| spellingShingle | Colmenero, P Zhang, A Qian, T Lu, L Cantor, H Söderström, K Engleman, E Qa-1(b)-dependent modulation of dendritic cell and NK cell cross-talk in vivo. |
| title | Qa-1(b)-dependent modulation of dendritic cell and NK cell cross-talk in vivo. |
| title_full | Qa-1(b)-dependent modulation of dendritic cell and NK cell cross-talk in vivo. |
| title_fullStr | Qa-1(b)-dependent modulation of dendritic cell and NK cell cross-talk in vivo. |
| title_full_unstemmed | Qa-1(b)-dependent modulation of dendritic cell and NK cell cross-talk in vivo. |
| title_short | Qa-1(b)-dependent modulation of dendritic cell and NK cell cross-talk in vivo. |
| title_sort | qa 1 b dependent modulation of dendritic cell and nk cell cross talk in vivo |
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