Accumulation of glucosylceramide in murine testis, caused by inhibition of beta-glucosidase 2: implications for spermatogenesis.

Accumulation of glucosylceramide in murine testis, caused by inhibition of beta-glucosidase 2: implications for spermatogenesis.

One of the hallmarks of male germ cell development is the formation of a specialized secretory organelle, the acrosome. This process can be pharmacologically disturbed in C57BL/6 mice, and thus infertility can be induced, by small molecular sugar-like compounds (alkylated imino sugars). Here the bio...

Descripció completa

Dades bibliogràfiques
Autors principals:	Walden, C, Sandhoff, R, Chuang, C, Yildiz, Y, Butters, T, Dwek, R, Platt, F, van der Spoel, A
Format:	Journal article
Idioma:	English
Publicat:	2007

Ítems similars

Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells.
per: Norris-Cervetto, E, et al.
Publicat: (2004)

Selective Inhibition of the Non-lysosomal Glucosylceramidase Gba2 and Elevation of Glucosylceramide in vivo: Consequences for Male Germ Cell Development
per: van der Spoel, A, et al.
Publicat: (2008)

Glucosylceramide modulates membrane traffic along the endocytic pathway.
per: Sillence, D, et al.
Publicat: (2002)

Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide.
per: D'Angelo, G, et al.
Publicat: (2007)

Glucosylated free oligosaccharides are biomarkers of endoplasmic- reticulum alpha-glucosidase inhibition.
per: Alonzi, D, et al.
Publicat: (2008)

Can P-glycoprotein influence the bioavailability of iminosugar-based glucosylceramide synthase inhibitors?
per: Norris-Cervetto, E, et al.
Publicat: (2006)

Long-term non-hormonal male contraception in mice using N-butyldeoxynojirimycin.
per: Walden, C, et al.
Publicat: (2006)

The alpha-glucosidase inhibitor N-butyldeoxynojirimycin inhibits human immunodeficiency virus entry at the level of post-CD4 binding.
per: Fischer, P, et al.
Publicat: (1995)

New synthetic seven-membered 1-azasugars displaying potent inhibition towards glycosidases and glucosylceramide transferase.
per: Li, H, et al.
Publicat: (2008)

Inhibition of glycosphingolipid biosynthesis: application to lysosomal storage disorders.
per: Butters, T, et al.
Publicat: (2000)

Gambaran histologik spermatogenesis tikus putih (Rattus norvegicus) setelah pemberian suntikan ekstrak testis kambing yang sudah dimurnikan
per: , GHUFRON, Muhammad, et al.
Publicat: (1989)

Design and synthesis of iminosugar-based inhibitors of glucosylceramide synthase: the search for new therapeutic agents against Gaucher disease
per: Boucheron, C, et al.
Publicat: (2005)

Glycosphingolipid changes in plasma in Parkinson’s disease independent of glucosylceramide levels
per: te Vruchte, D, et al.
Publicat: (2022)

Alkylated imino sugars, reversible male infertility-inducing agents, do not change the genetic integrity of male mouse germ cells, despite severe deformities of spermatozoal structures.
per: Suganuma, R, et al.
Publicat: (2004)

Alkylated imino sugars, reversible male infertility-inducing agents, do not affect the genetic integrity of male mouse germ cells during short-term treatment despite induction of sperm deformities.
per: Suganuma, R, et al.
Publicat: (2005)

N-butyldeoxynojirimycin causes weight loss as a result of appetite suppression in lean and obese mice.
per: Priestman, D, et al.
Publicat: (2008)

Improved cellular inhibitors for glycoprotein processing alpha-glucosidases: biological characterisation of alkyl- and arylalkyl-N-substituted deoxynojirimycins
per: Alonzi, D, et al.
Publicat: (2009)

The sensitivity of murine spermiogenesis to miglustat is a quantitative trait: a pharmacogenetic study.
per: Bone, W, et al.
Publicat: (2007)

A monoclonal antibody to glucosylceramide inhibits the growth of Fonsecaea pedrosoi and enhances the antifungal action of mouse macrophages.
per: Nimrichter, L, et al.
Publicat: (2004)

Glucosylceramide synthase inhibitors sensitise CLL cells to cytotoxic agents without reversing P-gp functional activity.
per: Gerrard, G, et al.
Publicat: (2009)

Inhibition of alpha-glucosidases I and II increases the cell surface expression of functional class A macrophage scavenger receptor (SR-A) by extending its half-life.
per: Tian, G, et al.
Publicat: (2004)

Characterization of glucosylceramides in Pseudallescheria boydii and their involvement in fungal differentiation.
per: Pinto, MR, et al.
Publicat: (2002)

α-Glucosidase inhibition of lactone intermediates of the iminosugar deoxynojirimycin
per: Wai Haan, Y, et al.
Publicat: (2019)

Inhibition of glycogen breakdown by imino sugars in vitro and in vivo.
per: Andersson, U, et al.
Publicat: (2004)

Iminosugars inhibit dengue virus production via inhibition of ER alpha-glucosidases – not glycolipid processing enzymes
per: Sayce, AC, et al.
Publicat: (2016)

Membrane disruption and cytotoxicity of hydrophobic N-alkylated imino sugars is independent of the inhibition of protein and lipid glycosylation.
per: Mellor, H, et al.
Publicat: (2003)

Design and synthesis of iminosugar-based inhibitors of glucosylceramide synthase: the search for new therapeutic agents against Gaucher disease (vol 16, pg 1747, 2005)
per: Boucheron, C, et al.
Publicat: (2005)

The role of Cdyl and CDY in mammalian spermatogenesis
per: Potash, Jesse
Publicat: (2006)

Pharmacological impairment of acrosome formation and sperm head morphogenesis reveals essential role of glycosphingolipids in spermiogenesis
per: van der Spoel, A, et al.
Publicat: (2002)

Potential beta-glucosidase inhibitor from Malaysian medical plants
per: Ahmad Barkat, Anumsima, et al.
Publicat: (2009)

Inhibition of membrane-associated viral replication
per: Block, T, et al.
Publicat: (2016)

Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin
per: Nazikussabah, Zaharudin, et al.
Publicat: (2019)

Glucosylceramide synthetase inhibitors sensitise B-CLL cells to cytotoxic agents without reversing P-gp functional activity.
per: Gerrard, G, et al.
Publicat: (2004)

Pengaruh Kadmium Klorida kadar rendah terhadap Spermatogenesis Ikan = Effect of low concentration of Cadmium Chloride on the Spermatogenesis of Fish
per: Perpustakaan UGM, i-lib
Publicat: (1992)

Deciphering the mitotic and meiotic phases of spermatogenesis in the mouse
per: Romer, Katherine A
Publicat: (2017)

Selfish mutations in Spermatogenesis and paternal age effects
per: Wilkie, A, et al.
Publicat: (2010)

Overexpression, purification and characterization of Aspergillus niger beta-glucosidase in Pichia pastoris
per: Kamaruddin, S., et al.
Publicat: (2015)

Cellular effects of deoxynojirimycin analogues: uptake, retention and inhibition of glycosphingolipid biosynthesis.
per: Mellor, H, et al.
Publicat: (2004)

Synthesis and biological characterisation of novel N-alkyl-deoxynojirimycin alpha-glucosidase inhibitors.
per: Rawlings, A, et al.
Publicat: (2009)

Synthesis of fluorescence-labelled disaccharide substrates of glucosidase II.
per: Cumpstey, I, et al.
Publicat: (2003)