Accumulation of glucosylceramide in murine testis, caused by inhibition of beta-glucosidase 2: implications for spermatogenesis.
One of the hallmarks of male germ cell development is the formation of a specialized secretory organelle, the acrosome. This process can be pharmacologically disturbed in C57BL/6 mice, and thus infertility can be induced, by small molecular sugar-like compounds (alkylated imino sugars). Here the bio...
Prif Awduron: | Walden, C, Sandhoff, R, Chuang, C, Yildiz, Y, Butters, T, Dwek, R, Platt, F, van der Spoel, A |
---|---|
Fformat: | Journal article |
Iaith: | English |
Cyhoeddwyd: |
2007
|
Eitemau Tebyg
-
Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells.
gan: Norris-Cervetto, E, et al.
Cyhoeddwyd: (2004) -
Selective Inhibition of the Non-lysosomal Glucosylceramidase Gba2 and Elevation of Glucosylceramide in vivo: Consequences for Male Germ Cell Development
gan: van der Spoel, A, et al.
Cyhoeddwyd: (2008) -
Glucosylceramide modulates membrane traffic along the endocytic pathway.
gan: Sillence, D, et al.
Cyhoeddwyd: (2002) -
Glucosylated free oligosaccharides are biomarkers of endoplasmic- reticulum alpha-glucosidase inhibition.
gan: Alonzi, D, et al.
Cyhoeddwyd: (2008) -
Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide.
gan: D'Angelo, G, et al.
Cyhoeddwyd: (2007)