Correlated and anticorrelated binocular disparity modulate GABA+ and glutamate/glutamine concentrations in the human visual cortex
Binocular disparity is used for perception and action in three dimensions. Neurons in the primary visual cortex respond to binocular disparity in random dot patterns, even when the contrast is inverted between eyes (false depth cue). In contrast, neurons in the ventral stream largely cease to respon...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Society for Neuroscience
2025
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| _version_ | 1824458866523373568 |
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| author | Matuszewski, J Ip, IB Alvarez, I Clarke, WT Parker, AJ Bridge, H |
| author_facet | Matuszewski, J Ip, IB Alvarez, I Clarke, WT Parker, AJ Bridge, H |
| author_sort | Matuszewski, J |
| collection | OXFORD |
| description | Binocular disparity is used for perception and action in three dimensions. Neurons in the primary visual cortex respond to binocular disparity in random dot patterns, even when the contrast is inverted between eyes (false depth cue). In contrast, neurons in the ventral stream largely cease to respond to false depth cues. This study evaluated whether GABAergic inhibition is involved in suppressing false depth cues in the human ventral visual cortex.
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We compared GABAergic inhibition (GABA+) and glutamatergic excitation (Glx) during the viewing of correlated and anticorrelated binocular disparity in 18 participants using single voxel proton magnetic-resonance spectroscopy (MRS). Measurements were taken from the early visual cortex (EVC) and the lateral occipital cortex (LO). Three visual conditions were presented per voxel location: correlated binocular disparity; anticorrelated binocular disparity; or a blank grey screen with a fixation cross. To identify differences in neurochemistry, GABA+ or Glx levels were compared across viewing conditions.
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In EVC, correlated disparity increased Glx over anticorrelated and rest conditions, also mirrored in the Glx/GABA+ ratio. In LO, anticorrelated disparity decreased GABA+ and increased Glx. The Glx/GABA+ ratio showed increased excitatory over inhibitory drive to anticorrelated disparity in LO. Glx during viewing of anticorrelation in LO was predictive of object-selective BOLD-activity in the same region.
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We provide evidence that early and ventral visual cortices change GABA+ and Glx concentrations during presentation of correlated and anticorrelated disparity, suggesting a contribution of cortical excitation and inhibition to disparity selectivity. |
| first_indexed | 2025-02-19T04:32:42Z |
| format | Journal article |
| id | oxford-uuid:22de57e1-d930-4501-8733-3303bdc231fc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2025-02-19T04:32:42Z |
| publishDate | 2025 |
| publisher | Society for Neuroscience |
| record_format | dspace |
| spelling | oxford-uuid:22de57e1-d930-4501-8733-3303bdc231fc2025-01-20T15:25:28ZCorrelated and anticorrelated binocular disparity modulate GABA+ and glutamate/glutamine concentrations in the human visual cortexJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:22de57e1-d930-4501-8733-3303bdc231fcEnglishSymplectic ElementsSociety for Neuroscience2025Matuszewski, JIp, IBAlvarez, IClarke, WTParker, AJBridge, HBinocular disparity is used for perception and action in three dimensions. Neurons in the primary visual cortex respond to binocular disparity in random dot patterns, even when the contrast is inverted between eyes (false depth cue). In contrast, neurons in the ventral stream largely cease to respond to false depth cues. This study evaluated whether GABAergic inhibition is involved in suppressing false depth cues in the human ventral visual cortex. <br> We compared GABAergic inhibition (GABA+) and glutamatergic excitation (Glx) during the viewing of correlated and anticorrelated binocular disparity in 18 participants using single voxel proton magnetic-resonance spectroscopy (MRS). Measurements were taken from the early visual cortex (EVC) and the lateral occipital cortex (LO). Three visual conditions were presented per voxel location: correlated binocular disparity; anticorrelated binocular disparity; or a blank grey screen with a fixation cross. To identify differences in neurochemistry, GABA+ or Glx levels were compared across viewing conditions. <br> In EVC, correlated disparity increased Glx over anticorrelated and rest conditions, also mirrored in the Glx/GABA+ ratio. In LO, anticorrelated disparity decreased GABA+ and increased Glx. The Glx/GABA+ ratio showed increased excitatory over inhibitory drive to anticorrelated disparity in LO. Glx during viewing of anticorrelation in LO was predictive of object-selective BOLD-activity in the same region. <br> We provide evidence that early and ventral visual cortices change GABA+ and Glx concentrations during presentation of correlated and anticorrelated disparity, suggesting a contribution of cortical excitation and inhibition to disparity selectivity. |
| spellingShingle | Matuszewski, J Ip, IB Alvarez, I Clarke, WT Parker, AJ Bridge, H Correlated and anticorrelated binocular disparity modulate GABA+ and glutamate/glutamine concentrations in the human visual cortex |
| title | Correlated and anticorrelated binocular disparity modulate GABA+ and glutamate/glutamine concentrations in the human visual cortex |
| title_full | Correlated and anticorrelated binocular disparity modulate GABA+ and glutamate/glutamine concentrations in the human visual cortex |
| title_fullStr | Correlated and anticorrelated binocular disparity modulate GABA+ and glutamate/glutamine concentrations in the human visual cortex |
| title_full_unstemmed | Correlated and anticorrelated binocular disparity modulate GABA+ and glutamate/glutamine concentrations in the human visual cortex |
| title_short | Correlated and anticorrelated binocular disparity modulate GABA+ and glutamate/glutamine concentrations in the human visual cortex |
| title_sort | correlated and anticorrelated binocular disparity modulate gaba and glutamate glutamine concentrations in the human visual cortex |
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