Delivery and long-term expression of a 135 kb LDLR genomic DNA locus in vivo by hydrodynamic tail vein injection.

Delivery and long-term expression of a 135 kb LDLR genomic DNA locus in vivo by hydrodynamic tail vein injection.

BACKGROUND: The delivery of a complete genomic DNA locus in vivo may prove advantageous for complementation gene therapy, especially when physiological regulation of gene expression is desirable. Hydrodynamic tail vein injection has been shown to be a highly efficient means of non-viral delivery of...

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Bibliographic Details
Main Authors:	Hibbitt, O, Harbottle, R, Waddington, SN, Bursill, C, Coutelle, C, Channon, K, Wade-Martins, R
Format:	Journal article
Language:	English
Published:	2007

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