Asymmetric synthesis of alpha-amino carbonyls (aldehydes, ketones and acids) using lithium (R)-N-benzyl-N-alpha-methylbenzylamide
The diastereoselective conjugate addition of lithium (R)-N-benzyl-N-α-methylbenzylamide to α,β-unsaturated esters and subsequent enolate hydroxylation, followed by reduction and oxidative cleavage provides a facile route to N,N-protected α-amino aldehydes and ketones. Further manipulation furnishes...
| Egile Nagusiak: | , , , |
|---|---|
| Formatua: | Journal article |
| Hizkuntza: | English |
| Argitaratua: |
2001
|