Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase.
The synthesis and inhibitory potencies of a novel series of 3,5-diaryl-1H-pyrazoles as specific inhibitors of prokaryotic arylamine N-acetyltransferase enzymes is described. The series is based on hit compound 1 3,5-diaryl-1H-pyrazole identified from a high-throughout screen that has been carried ou...
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Bibliographic Details
Main Authors: |
Fullam, E,
Talbot, J,
Abuhammed, A,
Westwood, I,
Davies, S,
Russell, A,
Sim, E |
Format: | Journal article
|
Language: | English |
Published: |
2013
|