The use of dioxygen by HIF prolyl hydroxylase (PHD1).
The hypoxic response in animals is mediated by hydroxylation of proline residues in the alpha-subunit of hypoxia inducible factor (HIF). Hydroxylation is catalysed by prolyl-4-hydroxylases (PHD isozymes in humans) which are iron(II) and 2-oxoglutarate dependent oxygenases. Mutation of the arginine p...
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Bibliographic Details
| Main Authors: |
McNeill, L,
Hewitson, K,
Gleadle, J,
Horsfall, L,
Oldham, N,
Maxwell, P,
Pugh, C,
Ratcliffe, P,
Schofield, C |
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| Format: | Journal article
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| Language: | English |
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| Published: |
2002
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