The use of dioxygen by HIF prolyl hydroxylase (PHD1).

The use of dioxygen by HIF prolyl hydroxylase (PHD1).

The hypoxic response in animals is mediated by hydroxylation of proline residues in the alpha-subunit of hypoxia inducible factor (HIF). Hydroxylation is catalysed by prolyl-4-hydroxylases (PHD isozymes in humans) which are iron(II) and 2-oxoglutarate dependent oxygenases. Mutation of the arginine p...

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Bibliographic Details
Main Authors:	McNeill, L, Hewitson, K, Gleadle, J, Horsfall, L, Oldham, N, Maxwell, P, Pugh, C, Ratcliffe, P, Schofield, C
Format:	Journal article
Language:	English
Published:	2002

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