Chemistry-to-gene screens in Caenorhabditis elegans.
The nematode worm Caenorhabditis elegans is a genetic model organism linked to an impressive portfolio of fundamental discoveries in biology. This free-living nematode, which can be easily and inexpensively grown in the laboratory, is also a natural vehicle for screening for drugs that are active ag...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2005
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| _version_ | 1797058263172251648 |
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| author | Jones, A Buckingham, S Sattelle, D |
| author_facet | Jones, A Buckingham, S Sattelle, D |
| author_sort | Jones, A |
| collection | OXFORD |
| description | The nematode worm Caenorhabditis elegans is a genetic model organism linked to an impressive portfolio of fundamental discoveries in biology. This free-living nematode, which can be easily and inexpensively grown in the laboratory, is also a natural vehicle for screening for drugs that are active against nematode parasites. Here, we show that chemistry-to-gene screens using this animal model can define targets of antiparasitic drugs, identify novel candidate drug targets and contribute to the discovery of new drugs for treating human diseases. |
| first_indexed | 2024-03-06T19:47:59Z |
| format | Journal article |
| id | oxford-uuid:22fc9f9f-81da-472a-93c3-f6b0b51a2f82 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:47:59Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:22fc9f9f-81da-472a-93c3-f6b0b51a2f822022-03-26T11:41:48ZChemistry-to-gene screens in Caenorhabditis elegans.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:22fc9f9f-81da-472a-93c3-f6b0b51a2f82EnglishSymplectic Elements at Oxford2005Jones, ABuckingham, SSattelle, DThe nematode worm Caenorhabditis elegans is a genetic model organism linked to an impressive portfolio of fundamental discoveries in biology. This free-living nematode, which can be easily and inexpensively grown in the laboratory, is also a natural vehicle for screening for drugs that are active against nematode parasites. Here, we show that chemistry-to-gene screens using this animal model can define targets of antiparasitic drugs, identify novel candidate drug targets and contribute to the discovery of new drugs for treating human diseases. |
| spellingShingle | Jones, A Buckingham, S Sattelle, D Chemistry-to-gene screens in Caenorhabditis elegans. |
| title | Chemistry-to-gene screens in Caenorhabditis elegans. |
| title_full | Chemistry-to-gene screens in Caenorhabditis elegans. |
| title_fullStr | Chemistry-to-gene screens in Caenorhabditis elegans. |
| title_full_unstemmed | Chemistry-to-gene screens in Caenorhabditis elegans. |
| title_short | Chemistry-to-gene screens in Caenorhabditis elegans. |
| title_sort | chemistry to gene screens in caenorhabditis elegans |
| work_keys_str_mv | AT jonesa chemistrytogenescreensincaenorhabditiselegans AT buckinghams chemistrytogenescreensincaenorhabditiselegans AT sattelled chemistrytogenescreensincaenorhabditiselegans |