Different pathways of colorectal carcinogenesis and their clinical pictures.
An entertaining debate in cancer genetics concerns the relative importance of selection for a growth advantage and genomic instability in tumorigenesis. Below, I present evidence that shows that selection is more important, particularly in the early stages of tumorigenesis, but that genomic instabil...
| Príomhchruthaitheoir: | |
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| Formáid: | Journal article |
| Teanga: | English |
| Foilsithe / Cruthaithe: |
2000
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| _version_ | 1826263203345072128 |
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| author | Tomlinson, I |
| author_facet | Tomlinson, I |
| author_sort | Tomlinson, I |
| collection | OXFORD |
| description | An entertaining debate in cancer genetics concerns the relative importance of selection for a growth advantage and genomic instability in tumorigenesis. Below, I present evidence that shows that selection is more important, particularly in the early stages of tumorigenesis, but that genomic instability is also an indisputable feature of many cancers. One attractive possibility is that some mutations may have pleiotropic effects both on cell replication or apoptosis and on genomic instability. |
| first_indexed | 2024-03-06T19:47:59Z |
| format | Journal article |
| id | oxford-uuid:22fd775b-b2a5-4a1c-a9c5-5a21f4ac90e4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:47:59Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:22fd775b-b2a5-4a1c-a9c5-5a21f4ac90e42022-03-26T11:41:48ZDifferent pathways of colorectal carcinogenesis and their clinical pictures.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:22fd775b-b2a5-4a1c-a9c5-5a21f4ac90e4EnglishSymplectic Elements at Oxford2000Tomlinson, IAn entertaining debate in cancer genetics concerns the relative importance of selection for a growth advantage and genomic instability in tumorigenesis. Below, I present evidence that shows that selection is more important, particularly in the early stages of tumorigenesis, but that genomic instability is also an indisputable feature of many cancers. One attractive possibility is that some mutations may have pleiotropic effects both on cell replication or apoptosis and on genomic instability. |
| spellingShingle | Tomlinson, I Different pathways of colorectal carcinogenesis and their clinical pictures. |
| title | Different pathways of colorectal carcinogenesis and their clinical pictures. |
| title_full | Different pathways of colorectal carcinogenesis and their clinical pictures. |
| title_fullStr | Different pathways of colorectal carcinogenesis and their clinical pictures. |
| title_full_unstemmed | Different pathways of colorectal carcinogenesis and their clinical pictures. |
| title_short | Different pathways of colorectal carcinogenesis and their clinical pictures. |
| title_sort | different pathways of colorectal carcinogenesis and their clinical pictures |
| work_keys_str_mv | AT tomlinsoni differentpathwaysofcolorectalcarcinogenesisandtheirclinicalpictures |