Interleukin-7 activates human naive CD4+ cells and primes for interleukin-4 production.
Interleukin (IL)-4 is considered to be essential for T helper (Th)2 cell development, yet in areas of primary T cell activation, CD4+ cells are its only source. This implies that other signals must drive the initial expression of IL-4 production. The role of CD28 co-stimulation in Th2 subset develop...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1997
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