MRI measurement of oxygen extraction fraction, mean vessel size and cerebral blood volume using serial hyperoxia and hypercapnia.
Functional magnetic resonance imaging measures signal increases arising from a variety of interrelated effects and physiological sources. Recently there has been some success in disentangling this signal in order to quantify baseline physiological parameters, including the resting oxygen extraction...
| المؤلفون الرئيسيون: | , |
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| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
Academic Press Inc.
2014
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| _version_ | 1826263209910206464 |
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| author | Germuska, M Bulte, D |
| author_facet | Germuska, M Bulte, D |
| author_sort | Germuska, M |
| collection | OXFORD |
| description | Functional magnetic resonance imaging measures signal increases arising from a variety of interrelated effects and physiological sources. Recently there has been some success in disentangling this signal in order to quantify baseline physiological parameters, including the resting oxygen extraction fraction (OEF), cerebral blood volume (CBV) and mean vessel size. However, due to the complicated nature of the signal, each of these methods relies on certain physiological assumptions to derive a solution. In this work we present a framework for the simultaneous, voxelwise measurement of these three parameters. The proposed method removes the assumption of a fixed vessel size from the quantification of OEF and CBV, while simultaneously removing the need for an assumed OEF in the calculation of vessel size. The new framework is explored through simulations and validated with a pilot study in healthy volunteers. The MRI protocol uses a combined hyperoxia and hypercapnia paradigm with a modified spin labelling sequence collecting multi-slice gradient echo and spin echo data. |
| first_indexed | 2024-03-06T19:48:05Z |
| format | Journal article |
| id | oxford-uuid:2306fc58-606f-4cc1-8d1b-d9e667c80ebc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:48:05Z |
| publishDate | 2014 |
| publisher | Academic Press Inc. |
| record_format | dspace |
| spelling | oxford-uuid:2306fc58-606f-4cc1-8d1b-d9e667c80ebc2022-03-26T11:41:59ZMRI measurement of oxygen extraction fraction, mean vessel size and cerebral blood volume using serial hyperoxia and hypercapnia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2306fc58-606f-4cc1-8d1b-d9e667c80ebcEnglishSymplectic Elements at OxfordAcademic Press Inc.2014Germuska, MBulte, DFunctional magnetic resonance imaging measures signal increases arising from a variety of interrelated effects and physiological sources. Recently there has been some success in disentangling this signal in order to quantify baseline physiological parameters, including the resting oxygen extraction fraction (OEF), cerebral blood volume (CBV) and mean vessel size. However, due to the complicated nature of the signal, each of these methods relies on certain physiological assumptions to derive a solution. In this work we present a framework for the simultaneous, voxelwise measurement of these three parameters. The proposed method removes the assumption of a fixed vessel size from the quantification of OEF and CBV, while simultaneously removing the need for an assumed OEF in the calculation of vessel size. The new framework is explored through simulations and validated with a pilot study in healthy volunteers. The MRI protocol uses a combined hyperoxia and hypercapnia paradigm with a modified spin labelling sequence collecting multi-slice gradient echo and spin echo data. |
| spellingShingle | Germuska, M Bulte, D MRI measurement of oxygen extraction fraction, mean vessel size and cerebral blood volume using serial hyperoxia and hypercapnia. |
| title | MRI measurement of oxygen extraction fraction, mean vessel size and cerebral blood volume using serial hyperoxia and hypercapnia. |
| title_full | MRI measurement of oxygen extraction fraction, mean vessel size and cerebral blood volume using serial hyperoxia and hypercapnia. |
| title_fullStr | MRI measurement of oxygen extraction fraction, mean vessel size and cerebral blood volume using serial hyperoxia and hypercapnia. |
| title_full_unstemmed | MRI measurement of oxygen extraction fraction, mean vessel size and cerebral blood volume using serial hyperoxia and hypercapnia. |
| title_short | MRI measurement of oxygen extraction fraction, mean vessel size and cerebral blood volume using serial hyperoxia and hypercapnia. |
| title_sort | mri measurement of oxygen extraction fraction mean vessel size and cerebral blood volume using serial hyperoxia and hypercapnia |
| work_keys_str_mv | AT germuskam mrimeasurementofoxygenextractionfractionmeanvesselsizeandcerebralbloodvolumeusingserialhyperoxiaandhypercapnia AT bulted mrimeasurementofoxygenextractionfractionmeanvesselsizeandcerebralbloodvolumeusingserialhyperoxiaandhypercapnia |